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Current Issues in Molecular Biology, Volume 46, Issue 7

July 2024 - 85 articles

Cover Story: Recurrent respiratory papillomatosis (RRP) is a benign disease of the upper aerodigestive tract caused by human papillomavirus (HPV) types 6 and 11. The molecular mechanisms of HPV infection in keratinocytes have been extensively studied throughout the years, with special attention being paid to its role in causing malignant tumors. A central role in this process is played by the vascular endothelial growth factor (VEGF), which activates different signaling cascades on multiple levels. This work summarizes current evidence about the role of VEGF in the pathophysiology of RRP, the molecular pathways activated by binding with its receptors, and the state of the art of antiangiogenic treatment. View this paper
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Articles (85)

  • Review
  • Open Access
7 Citations
10,054 Views
15 Pages

Breast cancer (BC) is the most commonly diagnosed tumor, remaining one of the leading causes of morbidity and mortality in females worldwide, with the highest rates in Western countries. Among metastatic BC (MBC), triple-negative breast cancer (TNBC)...

  • Review
  • Open Access
4 Citations
2,551 Views
19 Pages

Review on Long Non-Coding RNAs as Biomarkers and Potentially Therapeutic Targets for Bacterial Infections

  • Liqin Shi,
  • Xueya Han,
  • Fang Liu,
  • Jinzhao Long,
  • Yuefei Jin,
  • Shuaiyin Chen,
  • Guangcai Duan and
  • Haiyan Yang

The confrontation between humans and bacteria is ongoing, with strategies for combating bacterial infections continually evolving. With the advancement of RNA sequencing technology, non-coding RNAs (ncRNAs) associated with bacterial infections have g...

  • Case Report
  • Open Access
1 Citations
6,110 Views
10 Pages

Phytotherapy-Induced Hepatocytotoxicity: A Case Report

  • Stephen Malnick,
  • Ali Abdullah,
  • Yaacov Maor and
  • Manuela G. Neuman

Herbal and complementary medicine are frequently integrated with conventional medicine. We aim to report a case of severe herbal-induced liver injury (HILI) due to chronic use of green tea and protein shake. We present both clinical and laboratory ev...

  • Article
  • Open Access
3 Citations
2,239 Views
18 Pages

Erlotinib Treatment in Colorectal Cancer Suppresses Autophagy Based on KRAS Mutation

  • Alexander Siegman,
  • Aaron Shaykevich,
  • Danbee Chae,
  • Isaac Silverman,
  • Sanjay Goel and
  • Radhashree Maitra

The KRAS gene is mutated in approximately 45% of colorectal cancer patients. There are currently very few targeted treatments or therapies equipped to directly inhibit KRAS due to its unusual structural intricacies. Erlotinib, an EGFR inhibitor, has...

  • Review
  • Open Access
6 Citations
5,362 Views
14 Pages

Genetic and Non-Genetic Contributions to Eosinophilic Granulomatosis with Polyangiitis: Current Knowledge and Future Perspectives

  • Mirko Treccani,
  • Laura Veschetti,
  • Cristina Patuzzo,
  • Giovanni Malerba,
  • Augusto Vaglio and
  • Davide Martorana

In this work, we present a comprehensive overview of the genetic and non-genetic complexity of eosinophilic granulomatosis with polyangiitis (EGPA). EGPA is a rare complex systemic disease that occurs in people presenting with severe asthma and high...

  • Article
  • Open Access
1 Citations
1,804 Views
11 Pages

Effects of Sodium–Glucose Cotransporter 2 Inhibitors on Transcription Regulation of AgRP and POMC Genes

  • Dong Hee Kim,
  • Min Jin Lee,
  • Dasol Kang,
  • Ah Reum Khang,
  • Ji Hyun Bae,
  • Joo Yeon Kim,
  • Su Hyun Kim,
  • Yang Ho Kang and
  • Dongwon Yi

Sodium–glucose cotransporter 2 (SGLT2) inhibitors regulate plasma glucose levels in patients with type 2 diabetes mellitus (T2DM) by inhibiting renal glucose reabsorption. This study investigated the impact of empagliflozin (EMPA), an SGLT2 inh...

  • Review
  • Open Access
2 Citations
2,865 Views
19 Pages

Could Gas6/TAM Axis Provide Valuable Insights into the Pathogenesis of Systemic Sclerosis?

  • Daria Apostolo,
  • Davide D’Onghia,
  • Alessandra Nerviani,
  • Giulia Maria Ghirardi,
  • Daniele Sola,
  • Mattia Perazzi,
  • Stelvio Tonello,
  • Donato Colangelo,
  • Pier Paolo Sainaghi and
  • Mattia Bellan

Systemic sclerosis (SSc) is a connective tissue disorder characterized by microvascular injury, extracellular matrix deposition, autoimmunity, inflammation, and fibrosis. The clinical complexity and high heterogeneity of the disease make the discover...

  • Article
  • Open Access
4 Citations
2,263 Views
13 Pages

Differential Digestive Stability of Food-Derived microRNAs: The Case of miR-30c-5p and miR-92a-3p in Polyfloral Honey

  • Diana Marisol Abrego-Guandique,
  • Olubukunmi Amos Ilori,
  • Maria Cristina Caroleo,
  • Roberto Cannataro,
  • Erika Cione and
  • Paola Tucci

Dietary microRNAs (miRs) represent a new area in food science. Although they have been found in many foods, including honey, more research is needed about their stability and fate during digestion. Hence, this study aimed to analyze the digestive sta...

  • Review
  • Open Access
25 Citations
9,083 Views
26 Pages

Emerging Strategies against Non-Typhoidal Salmonella: From Pathogenesis to Treatment

  • Cristina Mihaela Sima,
  • Elena Roxana Buzilă,
  • Felicia Trofin,
  • Diana Păduraru,
  • Cătălina Luncă,
  • Alexandru Duhaniuc,
  • Olivia Simona Dorneanu and
  • Eduard Vasile Nastase

Even with the intensive efforts by public health programs to control and prevent it, non-typhoidal Salmonella (NTS) infection remains an important public health challenge. It is responsible for approximately 150 million illnesses and 60,000 deaths wo...

  • Article
  • Open Access
8 Citations
2,448 Views
17 Pages

Epigenetic and Molecular Alterations in Obesity: Linking CRP and DNA Methylation to Systemic Inflammation

  • Ciprian Cucoreanu,
  • Adrian-Bogdan Tigu,
  • Madalina Nistor,
  • Radu-Cristian Moldovan,
  • Ioana-Ecaterina Pralea,
  • Maria Iacobescu,
  • Cristina-Adela Iuga,
  • Robert Szabo,
  • George-Calin Dindelegan and
  • Constatin Ciuce

Obesity is marked by excessive fat accumulation in the adipose tissue, which disrupts metabolic processes and causes chronic systemic inflammation. Commonly, body mass index (BMI) is used to assess obesity-related risks, predicting potential metaboli...

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Curr. Issues Mol. Biol. - ISSN 1467-3045