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Current Issues in Molecular Biology, Volume 46, Issue 8

August 2024 - 85 articles

Cover Story: Skin stem cells (SCs) are crucial for skin tissue maintenance and regeneration, including bulge SCs and those in the interfollicular epidermis, infundibulum, isthmus, sebaceous glands, and sweat glands. These SCs originate during embryogenesis from various precursors, forming the diverse SC pool in adult skin, essential for repair and regeneration. Molecular signals regulate SC behavior, balancing rest, self-renewal, and differentiation. Disrupting this balance can cause SC exhaustion, poor healing, and skin cancer. This review examines SC development, activation, and differentiation mechanisms, focusing on molecular pathways that govern their fate. Understanding these pathways enhances skin biology knowledge and aids in developing regenerative medicine for skin disorders and injuries. View this paper
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Articles (85)

  • Article
  • Open Access
3 Citations
11,465 Views
11 Pages

22 August 2024

Parkinson’s disease (PD) is the second leading neurodegenerative disease after Alzheimer’s disease. Mucuna pruriens (L.) DC. (MP) is a plant that contains Levodopa (L-DOPA) and has been known to improve the symptoms of PD. In this prelimi...

  • Article
  • Open Access
6 Citations
3,101 Views
19 Pages

22 August 2024

The thymus, a central lymphoid organ in animals, serves as the site for T cell development, differentiation and maturation, vital to adaptive immunity. The thymus is critical for maintaining tissue homeostasis to protect against tumors and tissue dam...

  • Review
  • Open Access
10 Citations
5,317 Views
36 Pages

Two Decades of Advances and Limitations in Organ Recellularization

  • Alina Stoian,
  • Aisha Adil,
  • Felor Biniazan and
  • Siba Haykal

22 August 2024

The recellularization of tissues after decellularization is a relatively new technology in the field of tissue engineering (TE). Decellularization involves removing cells from a tissue or organ, leaving only the extracellular matrix (ECM). This can t...

  • Article
  • Open Access
2,655 Views
17 Pages

The Molecular Signature Related to Local Inflammatory and Immune Response in Canine Cutaneous Hypersensitivity Reactions: A Preliminary Study

  • Camilla Capaccia,
  • Francesco Ciancabilla,
  • Ilaria Porcellato,
  • Chiara Brachelente,
  • Massimo Zerani,
  • Margherita Maranesi and
  • Gabriella Guelfi

22 August 2024

Cutaneous hypersensitivity reactions (CHRs) are complex inflammatory skin disorders that affect humans and dogs. This study examined the inflammatory and immune responses leading to skin damage, inflammation, and irritation by investigating gene expr...

  • Review
  • Open Access
18 Citations
4,860 Views
13 Pages

22 August 2024

Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial resistance to current antibiotics, the...

  • Article
  • Open Access
5 Citations
2,101 Views
13 Pages

21 August 2024

Skin healing occurs through an intricate process called wound healing which comprises four phases: coagulation and hemostasis, inflammation, cellular proliferation, and remodeling. Chronic wounds often arise because of prolonged or excessive inflamma...

  • Article
  • Open Access
1 Citations
1,779 Views
14 Pages

20 August 2024

Skin aging is a complex process with internal and external factors. Recent studies have suggested that enlargement and elongation of skin pores may be early signs of aging in addition to wrinkles and loss of elasticity. This study explores the potent...

  • Review
  • Open Access
3 Citations
7,101 Views
29 Pages

Unlocking the Genetic Secrets of Acromegaly: Exploring the Role of Genetics in a Rare Disorder

  • Ioana Balinisteanu,
  • Lavinia Caba,
  • Andreea Florea,
  • Roxana Popescu,
  • Laura Florea,
  • Maria-Christina Ungureanu,
  • Letitia Leustean,
  • Eusebiu Vlad Gorduza and
  • Cristina Preda

20 August 2024

Acromegaly is a rare endocrine disorder characterized by the excessive production of growth hormone (GH) in adulthood. Currently, it is understood that certain pituitary neuroendocrine tumors (PitNETs) exhibit a hereditary predisposition. These tumor...

  • Article
  • Open Access
1 Citations
5,102 Views
11 Pages

Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model

  • Hyeyeon Chun,
  • Hyejin Lee,
  • Jongwook Kim,
  • Hyerin Yeo,
  • Kyongeun Hyung,
  • Dayoung Song,
  • Moonju Kim,
  • Seung-Hyun Jun and
  • Nae-Gyu Kang

20 August 2024

Skin radiance is crucial for enhancing facial attractiveness and is negatively affected by factors like hyperpigmentation and aging-related changes. Current treatments often lack comprehensive solutions for improving skin radiance. This study aimed t...

  • Communication
  • Open Access
3 Citations
1,760 Views
8 Pages

19 August 2024

Although previous studies have examined the relationship between obesity and genetics in response to the growing obesity epidemic, research on the relationship between obesity and long-term changes in body mass index (BMI) is limited. To investigate...

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Curr. Issues Mol. Biol. - ISSN 1467-3045