Advances and Challenges in Organ Decellularization and Recellularization

Dear Colleagues,

Transplantation is the only curative treatment option for patients with end-stage organ failure, improving their long-term survival. However, alternative treatment options are needed due to disadvantages such as organ scarcity. In recent years, whole organ decellularization and recellularization techniques have attracted increasing attention.

Decellularization is the process by which cells are expelled from tissues or organs, and through decellularization, these organs can be used as scaffolds for the development of new functional organs. For recellularization, these biological scaffolds are subsequently repopulated with patient-sourced specific cells, resulting in the construction of a functional new organ that eliminates the risk of immune rejection.

Currently, decellularization and recellularization techniques have made substantial progress in the field of organ bioengineering. However, there is still room for progress in a range of issues such as decellularized scaffold selection, successful endothelialization, and the overall functional maturity of engineered tissues and organs. In this Special Issue, we focus on the actual state of organ decellularization and recellularization, as well as problems and future challenges.

We invite experts to share their valuable insights, new data, or comprehensive systematic evaluations in this emerging and critical field.

Dr. Aylin Acun
Guest Editor

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• organ engineering
• decellularization
• recellularization
• endothelialization
• extracellular matrix
• regenerative medicine