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Pharmaceuticals, Volume 17, Issue 11

November 2024 - 150 articles

Cover Story: Freeze-drying is a dehydration method that extends the shelf life and stability of drugs, vaccines, and biologics. Recently, its role has expanded beyond preservation to improve novel pharmaceuticals and their carriers, such as hydrogels, which are widely studied for both drug delivery and wound healing. This article highlights the multifunctional role of freeze-drying in improving the properties of sodium alginate/poly(vinyl alcohol)-based hydrogels for pharmaceutical delivery. The results show a high potential for commercialisation of the obtained hydrogels as medical dressings. View this paper
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Articles (150)

  • Article
  • Open Access
2 Citations
3,913 Views
22 Pages

16 November 2024

Background: Artemisia annua, a plant with antiviral potential, has shown promise against various viral infections, yet its mechanisms of action are not fully understood. This study explores A. annua’s antiviral effects using network pharmacolog...

  • Article
  • Open Access
3 Citations
12,170 Views
12 Pages

Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus

  • Juozas R. Lazutka,
  • Kristina Daniūnaitė,
  • Veronika Dedonytė,
  • Aistė Popandopula,
  • Karolina Žukaitė,
  • Žydrūnė Visockienė and
  • Laura Šiaulienė

16 November 2024

Background/Objectives: Diabetes mellitus (DM) is a complex and heterogenous disease classified as a group of metabolic disorders characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It leads to...

  • Review
  • Open Access
7 Citations
5,337 Views
16 Pages

Antibacterial Mechanisms and Clinical Impact of Sitafloxacin

  • Elian M. A. Kuhn,
  • Levy A. Sominsky,
  • Marco Chittò,
  • Edward M. Schwarz and
  • T. Fintan Moriarty

16 November 2024

Sitafloxacin is a 4th generation fluoroquinolone antibiotic with broad activity against a wide range of Gram-negative and Gram-positive bacteria. It is approved in Japan and used to treat pneumonia and urinary tract infections (UTIs) as well as other...

  • Article
  • Open Access
3 Citations
1,805 Views
19 Pages

15 November 2024

Background: Histone deacetylase 6 (HDAC6) plays a crucial role in neurological, inflammatory, and other diseases; thus, it has emerged as an important target for therapeutic intervention. To date, there are no FDA-approved HDAC6-targeting drugs, and...

  • Article
  • Open Access
3 Citations
1,738 Views
21 Pages

Corema album Berry Juice as a Protective Agent Against Neurodegeneration

  • Antonio Canoyra,
  • Carmen Martín-Cordero,
  • Dolores Muñoz-Mingarro,
  • Antonio J. León-González,
  • Richard B. Parsons and
  • Nuria Acero

15 November 2024

Background/Objectives: Corema album berries are edible fruits from the Iberian Atlantic coast, characterized by a rich polyphenolic composition, which endows their juice with potential protective effects against neurodegeneration. This study aimed to...

  • Article
  • Open Access
2 Citations
1,355 Views
18 Pages

Phytochemicals from Passiflora coriacea Juss. Have Anti-Inflammatory and Neuroprotective Effects in Mouse Models

  • Samir Castolo-Sanchez,
  • Alejandro Zamilpa,
  • Maribel Herrera-Ruiz,
  • José Luis Trejo-Espino,
  • Blanca Eda Domínguez-Mendoza,
  • Manasés González-Cortazar and
  • Gabriela Trejo-Tapia

15 November 2024

Background: Neuroinflammatory diseases trigger an inflammatory response and a state of oxidative stress. Passiflora coriacea Juss. has been used to treat conditions related to inflammatory processes in the central nervous system; however, to date, th...

  • Correction
  • Open Access
804 Views
3 Pages

15 November 2024

In the original publication [...]

  • Article
  • Open Access
2 Citations
3,023 Views
25 Pages

Discovery of New 3-(Benzo[b]Thiophen-2-yl)Pyrrolidine-2,5-Dione Derivatives as Potent Antiseizure and Antinociceptive Agents—In Vitro and In Vivo Evaluation

  • Anna Rapacz,
  • Marcin Jakubiec,
  • Michał Abram,
  • Jakub Jasiński,
  • Karolina Chrzan,
  • Małgorzata Góra,
  • Anna Dziubina,
  • Katarzyna Wójcik-Pszczoła,
  • Paulina Koczurkiewicz-Adamczyk and
  • Katarzyna Ciepiela
  • + 3 authors

15 November 2024

Background/Objectives: To address the unmet clinical needs in the treatment of epilepsy and pain, the continued development of more effective and safer anticonvulsants and analgesics is still necessary. Therefore, herein we report synthesis and antis...

  • Article
  • Open Access
1 Citations
3,310 Views
12 Pages

The Use of Osteogenon as an Adjunctive Treatment in Lower Leg Fractures

  • Piotr Morasiewicz,
  • Monika Zaborska,
  • Michał Sobczak,
  • Łukasz Tomczyk,
  • Paweł Leyko,
  • Andrzej Bobiński,
  • Joanna Kochańska-Bieri,
  • Daniele Pili and
  • Krystian Kazubski

14 November 2024

Background: The goal of the orthopedic treatment of fractures is to achieve bone union as rapidly as possible in the largest possible number of patients and to minimize the number of complications. The purpose of this study was to assess if the use o...

  • Article
  • Open Access
1 Citations
1,664 Views
19 Pages

Sustainable Intervention: Grape Pomace Flour Ameliorates Fasting Glucose and Mitigates Streptozotocin-Induced Pancreatic Damage in a Type 2 Diabetes Animal Model

  • Raphaela Cassol Piccoli,
  • William Sanabria Simões,
  • Solange Vega Custódio,
  • Kelen Cristiane Machado Goularte,
  • Karina Pereira Luduvico,
  • Julia Eisenhardt de Mello,
  • Anita Avila de Souza,
  • Ana Carolina Teixeira,
  • Diego Araujo da Costa and
  • Alethéa Gatto Barschak
  • + 8 authors

14 November 2024

Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, increased risk of cardiovascular diseases, and oxidative imbalances. This study aimed to investigate the impact of dietary supplementations with ‘Arinto&r...

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Pharmaceuticals - ISSN 1424-8247