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Sensors 2006, 6(11), 1523-1536;

Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode

Department of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
Authors to whom correspondence should be addressed.
Received: 14 August 2006 / Accepted: 3 November 2006 / Published: 8 November 2006
(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)
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An improvement of selectivity for electrochemical detection of dopamine (DA)with differential pulse voltammetry is achieved by covalently modifying a glassy carbonelectrode (GCE) with O-carboxymethylchitosan (OCMCS). The amphiphilic chitosanprovides electrostatic accumulation of DA onto the electrode surface. In a phosphate buffersolution (pH 6.0), a pair of well-defined reversible redox waves of DA was observed at theOCMCS/GCE with a δEp of 52 mV. The anodic peak current obtained from thedifferential pulse voltammetry of dopamine was linearly dependent on its concentration inthe range of 6.0 × 10-8 to 7.0 × 10-6 M, with a correlation coefficient of 0.998. Thedetection limit (S/N = 3) was found to be 1.5 × 10-9 M. The modified electrode had beenapplied to the determination of DA in human serum samples with satisfactory results. View Full-Text
Keywords: O-carboxymethylchitosan; chitosan; dopamine; voltammetry; human serum O-carboxymethylchitosan; chitosan; dopamine; voltammetry; human serum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, C.Y.; Wang, Z.X.; Zhu, A.P.; Hu, X.Y. Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode. Sensors 2006, 6, 1523-1536.

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