5′-Chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine
1
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Sergio Pansini, 5, 80131 Napoli, Italy
2
Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1097; https://doi.org/10.3390/M1097
Received: 20 November 2019 / Revised: 7 December 2019 / Accepted: 10 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Molecules from Side Reactions)
In this paper, we report on the synthesis and spectroscopic characterization of the novel nucleoside 5′-chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine, obtained as a side product during the second step of the synthesis of 5′-fluoro-5′-deoxy-5-aminoimidazole-4-carboxamide-β-d-riboside (5′-F-AICAR), a non-phosphorylable analogue of 5-aminoimidazole-4-carboxamide-β-d-riboside (AICAR).
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Keywords:
AICAR; acadesine; phosphorylation; fluorination; fluorinated nucleosides; nucleoside analogues; modified nucleosides; chlorinated nucleosides; AMPK
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Falanga, A.P.; Marzano, M.; Terracciano, M.; D'Errico, S. 5′-Chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine. Molbank 2019, 2019, M1097.
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