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Open AccessFeature PaperShort Note

5′-Chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine

1
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Sergio Pansini, 5, 80131 Napoli, Italy
2
Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1097; https://doi.org/10.3390/M1097
Received: 20 November 2019 / Revised: 7 December 2019 / Accepted: 10 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Molecules from Side Reactions)
In this paper, we report on the synthesis and spectroscopic characterization of the novel nucleoside 5′-chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine, obtained as a side product during the second step of the synthesis of 5′-fluoro-5′-deoxy-5-aminoimidazole-4-carboxamide-β-d-riboside (5′-F-AICAR), a non-phosphorylable analogue of 5-aminoimidazole-4-carboxamide-β-d-riboside (AICAR). View Full-Text
Keywords: AICAR; acadesine; phosphorylation; fluorination; fluorinated nucleosides; nucleoside analogues; modified nucleosides; chlorinated nucleosides; AMPK AICAR; acadesine; phosphorylation; fluorination; fluorinated nucleosides; nucleoside analogues; modified nucleosides; chlorinated nucleosides; AMPK
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MDPI and ACS Style

Falanga, A.P.; Marzano, M.; Terracciano, M.; D'Errico, S. 5′-Chloro-5′-deoxy-2′,3′-O-isopropylidene-6-fluoro nebularine. Molbank 2019, 2019, M1097.

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