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Article

Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors

by
Gabriele Murineddu
1,*,
Erika Plicanti
2,
Paola Corona
1,
Carlo Di Marzo
2,
Battistina Asproni
1,
Ilenia Lupinu
3,
Giulia Lottini
2,
Sandra Piras
1 and
Antonio Carta
1
1
Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy
2
Centro Retrovirus, Department of Translational Research, University of Pisa, 56127 Pisa, Italy
3
Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(5), 2306; https://doi.org/10.3390/ijms27052306
Submission received: 26 January 2026 / Revised: 21 February 2026 / Accepted: 27 February 2026 / Published: 28 February 2026
(This article belongs to the Special Issue Antiviral Drugs Discovery)
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Abstract

A small library of 23 pyrrole-based tricyclic derivatives bearing bulky amine moieties was synthesized, and all were evaluated for their antiviral activities against ZIKV and SARS-CoV. Three compounds, derivatives 2g, 2h and 2j, elicited interesting activity against ZIKV: compound 2g, containing a bornylamine residue, showed the best activity against Huh-7 cells with EC50 and CC50 values of 0.4 μM and 230.5 μM, respectively, and a Selectivity Index (SI) of 501. All three compounds reduce ZIKV yield primarily by impairing viral protein.
Keywords: synthesis of tricyclic pyrroles; antiviral activity; Western blot analysis synthesis of tricyclic pyrroles; antiviral activity; Western blot analysis

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MDPI and ACS Style

Murineddu, G.; Plicanti, E.; Corona, P.; Di Marzo, C.; Asproni, B.; Lupinu, I.; Lottini, G.; Piras, S.; Carta, A. Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors. Int. J. Mol. Sci. 2026, 27, 2306. https://doi.org/10.3390/ijms27052306

AMA Style

Murineddu G, Plicanti E, Corona P, Di Marzo C, Asproni B, Lupinu I, Lottini G, Piras S, Carta A. Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors. International Journal of Molecular Sciences. 2026; 27(5):2306. https://doi.org/10.3390/ijms27052306

Chicago/Turabian Style

Murineddu, Gabriele, Erika Plicanti, Paola Corona, Carlo Di Marzo, Battistina Asproni, Ilenia Lupinu, Giulia Lottini, Sandra Piras, and Antonio Carta. 2026. "Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors" International Journal of Molecular Sciences 27, no. 5: 2306. https://doi.org/10.3390/ijms27052306

APA Style

Murineddu, G., Plicanti, E., Corona, P., Di Marzo, C., Asproni, B., Lupinu, I., Lottini, G., Piras, S., & Carta, A. (2026). Tricyclic Pyrrole-Based Compounds as Zika Virus Inhibitors. International Journal of Molecular Sciences, 27(5), 2306. https://doi.org/10.3390/ijms27052306

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