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Volume 26
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Retraction of Int. J. Mol. Sci. 2022, 23(16), 9368.
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Retraction

RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368

by
Qihui Luo
1,2,†,
Lanlan Jia
1,2,†,
Chao Huang
1,2,
Qi Qi
1,
Asad Jahangir
1,
Yu Xia
1,
Wentao Liu
1,2,
Riyi Shi
3,
Li Tang
2 and
Zhengli Chen
1,2,*
1
Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
3
Center for Paralysis Research & Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(23), 11528; https://doi.org/10.3390/ijms262311528 (registering DOI)
Submission received: 5 November 2025 / Accepted: 6 November 2025 / Published: 28 November 2025
(This article belongs to the Special Issue Advance in Targeted Cancer Therapy and Mechanisms of Resistance)
Versions Notes
The journal retracts the article titled “Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway” [1], cited above.
Following publication, the authors contacted the Editorial Office to raise concerns relating to Figure 2A(a) and Figure 2B(a), which appears to be the same image. As Figure 2A(a) and Figure 2B(a) were both without PPI treatment, we misused the images when we disposed of the data of this manuscript.
Adhering to our standard procedure, the Editorial Office and Editorial Board conducted an investigation that confirmed Figure 2A(a) and Figure 2B(a) are the same image. As a result, the Editorial Office, Editorial Board, and authors have decided to retract this article as per MDPI’s retraction policy (https://www.mdpi.com/ethics#_bookmark30, accessed on 1 November 2025).
This retraction was approved by the Editor-in-Chief of the IJMS journal.
The authors agreed to this retraction.

Reference

  1. Luo, Q.; Jia, L.; Huang, C.; Qi, Q.; Jahangir, A.; Xia, Y.; Liu, W.; Shi, R.; Tang, L.; Chen, Z. RETRACTED: Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368. [Google Scholar] [CrossRef] [PubMed]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Luo, Q.; Jia, L.; Huang, C.; Qi, Q.; Jahangir, A.; Xia, Y.; Liu, W.; Shi, R.; Tang, L.; Chen, Z. RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368. Int. J. Mol. Sci. 2025, 26, 11528. https://doi.org/10.3390/ijms262311528

AMA Style

Luo Q, Jia L, Huang C, Qi Q, Jahangir A, Xia Y, Liu W, Shi R, Tang L, Chen Z. RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368. International Journal of Molecular Sciences. 2025; 26(23):11528. https://doi.org/10.3390/ijms262311528

Chicago/Turabian Style

Luo, Qihui, Lanlan Jia, Chao Huang, Qi Qi, Asad Jahangir, Yu Xia, Wentao Liu, Riyi Shi, Li Tang, and Zhengli Chen. 2025. "RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368" International Journal of Molecular Sciences 26, no. 23: 11528. https://doi.org/10.3390/ijms262311528

APA Style

Luo, Q., Jia, L., Huang, C., Qi, Q., Jahangir, A., Xia, Y., Liu, W., Shi, R., Tang, L., & Chen, Z. (2025). RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int. J. Mol. Sci. 2022, 23, 9368. International Journal of Molecular Sciences, 26(23), 11528. https://doi.org/10.3390/ijms262311528

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