Next Article in Journal
Special Issue “Molecular Mechanisms and Pathophysiology of Sepsis”
Next Article in Special Issue
Istaroxime in Acute Heart Failure and Early Cardiogenic Shock: A Calcium-Cycling Approach to Inotropic Therapy
Previous Article in Journal
Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy
Previous Article in Special Issue
Arthrospira Platensis Attenuates Endothelial Inflammation and Monocyte Activation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 19
10.3390/ijms26199550
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

by
Francesco Canonico
1,
Renzo Laborante
2,
Chiara Pidone
2,
Ramona Vinci
2,
Mattia Galli
3,4,
Eugenia Pisano
2,
Alice Bonanni
2,
Marianna Di Sario
2,
Anna Severino
5,
Lucia Lisi
6,
Daniela Pedicino
5,
Giovanna Liuzzo
2,5,
Massimiliano Ruscica
7,8,
Filippo Crea
2,9,
Giuseppe Patti
1,10 and
Domenico D’Amario
1,10,*
1
Department of Thoracic and Cardiovascular Diseases, Azienda Ospedaliero-Universitaria Maggiore Della Carità, 28100 Novara, Italy
2
Department of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy
3
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
4
GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
5
Department of Cardiovascular Sciences, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy
6
Department of Pharmacology, Catholic University of Sacred Heart, 00168 Rome, Italy
7
Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy
8
Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, 20152 Milan, Italy
9
Center of Excellence of Cardiovascular Sciences, Ospedale Isola Tiberina—Gemelli Isola, 00186 Rome, Italy
10
Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(19), 9550; https://doi.org/10.3390/ijms26199550
Submission received: 4 July 2025 / Revised: 22 September 2025 / Accepted: 26 September 2025 / Published: 30 September 2025
(This article belongs to the Special Issue Molecular Pathophysiology and Treatment of Coronary Artery Disease)
Browse Figures
Review Reports Versions Notes

Abstract

PLIN2 is involved in the lipid metabolism of macrophages resident in atherosclerotic plaques, and its upregulation leads to lipid droplets (LDs) accumulation. LDs enlargement results in the macrophage transformation into foam cells, a key step for the onset of atherosclerosis. In the present study, we investigated the role of PLIN2 and its regulation mechanisms in atherosclerosis and plaque instability in patients with a diagnosis of ST-elevation myocardial infarction (STEMI) and chronic coronary syndrome (CCS). We enrolled STEMI (n = 122) and CCS patients (n = 45). Peripheral blood mononuclear cells were isolated from whole blood samples. The PLIN2 protein level was analyzed in CD14+ monocytes by flow cytometry. Lipidomic panel and proteasome activity were evaluated. PLIN2 protein expression was significantly correlated with the age of CAD patients. We found no significant difference in monocyte lipid content between the two patient groups. The PLIN2 increased in STEMI as compared to CCS patients (p < 0.001). The proteasome activity being higher in STEMI as compared to CCS patients (p < 0.001), significant inverse correlations were evident between PLIN2 levels and proteasome activity in the CCS groups (p = 0.02). PLIN2 expression was higher in STEMI as compared to CCS patients, suggesting an involvement in plaque instability. Despite the proteasome activity being higher in STEMI patients, probably due to the elevated inflammatory burden, PLIN2 could escape proteasome degradation in a more efficient manner in STEMI as compared to CCS patients.
Keywords: PLIN2; STEMI; CCS; proteasome activity; oxidative stress; plaque instability PLIN2; STEMI; CCS; proteasome activity; oxidative stress; plaque instability
Graphical Abstract

Share and Cite

MDPI and ACS Style

Canonico, F.; Laborante, R.; Pidone, C.; Vinci, R.; Galli, M.; Pisano, E.; Bonanni, A.; Di Sario, M.; Severino, A.; Lisi, L.; et al. Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications. Int. J. Mol. Sci. 2025, 26, 9550. https://doi.org/10.3390/ijms26199550

AMA Style

Canonico F, Laborante R, Pidone C, Vinci R, Galli M, Pisano E, Bonanni A, Di Sario M, Severino A, Lisi L, et al. Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications. International Journal of Molecular Sciences. 2025; 26(19):9550. https://doi.org/10.3390/ijms26199550

Chicago/Turabian Style

Canonico, Francesco, Renzo Laborante, Chiara Pidone, Ramona Vinci, Mattia Galli, Eugenia Pisano, Alice Bonanni, Marianna Di Sario, Anna Severino, Lucia Lisi, and et al. 2025. "Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications" International Journal of Molecular Sciences 26, no. 19: 9550. https://doi.org/10.3390/ijms26199550

APA Style

Canonico, F., Laborante, R., Pidone, C., Vinci, R., Galli, M., Pisano, E., Bonanni, A., Di Sario, M., Severino, A., Lisi, L., Pedicino, D., Liuzzo, G., Ruscica, M., Crea, F., Patti, G., & D’Amario, D. (2025). Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications. International Journal of Molecular Sciences, 26(19), 9550. https://doi.org/10.3390/ijms26199550

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop