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Volume 26
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10.3390/ijms26199545
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Review

Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy

by
Adina Zamfir-Chiru-Anton
1,2,
Dana Manda
3,* and
Dan-Cristian Gheorghe
2,4
1
“Grigore Alexandrescu” Emergency Hospital for Children, 011743 Bucharest, Romania
2
Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
3
“C.I. Parhon” National Institute of Endocrinology, 011863 Bucharest, Romania
4
“Marie Curie” Emergency Hospital for Children, 077120 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(19), 9545; https://doi.org/10.3390/ijms26199545
Submission received: 11 August 2025 / Revised: 27 September 2025 / Accepted: 29 September 2025 / Published: 30 September 2025
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Cholesteatoma is a prevalent disease affecting both children and adults. In this review, we present the recent findings related to the molecular mechanisms involved in cholesteatoma and discuss how researchers can target new molecules to treat this disease. These new approaches illustrate the paradigm shift from a primarily surgical solution to a biological “control and prevent” strategy.
Keywords: cholesteatoma; personalized medicine; middle ear cholesteatoma; personalized medicine; middle ear

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MDPI and ACS Style

Zamfir-Chiru-Anton, A.; Manda, D.; Gheorghe, D.-C. Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy. Int. J. Mol. Sci. 2025, 26, 9545. https://doi.org/10.3390/ijms26199545

AMA Style

Zamfir-Chiru-Anton A, Manda D, Gheorghe D-C. Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy. International Journal of Molecular Sciences. 2025; 26(19):9545. https://doi.org/10.3390/ijms26199545

Chicago/Turabian Style

Zamfir-Chiru-Anton, Adina, Dana Manda, and Dan-Cristian Gheorghe. 2025. "Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy" International Journal of Molecular Sciences 26, no. 19: 9545. https://doi.org/10.3390/ijms26199545

APA Style

Zamfir-Chiru-Anton, A., Manda, D., & Gheorghe, D.-C. (2025). Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy. International Journal of Molecular Sciences, 26(19), 9545. https://doi.org/10.3390/ijms26199545

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