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Volume 26
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Review

Monocyte Involvement in the Pathogenesis of Myeloproliferative Neoplasms

by
Xuedong Li
1,2,
Mingli Xu
1,2 and
Yingying Wang
1,2,*
1
Department of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China
2
Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, Chongqing 400016, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(13), 6422; https://doi.org/10.3390/ijms26136422
Submission received: 29 May 2025 / Revised: 30 June 2025 / Accepted: 1 July 2025 / Published: 3 July 2025
(This article belongs to the Special Issue New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms)
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Abstract

Classical BCR-ABL-negative myeloproliferative neoplasms are a heterogeneous group of hematologic malignancies, including essential thrombocythemia, polycythemia vera, and primary myelofibrosis. Monocytes, immune cells derived from hematopoietic stem cells, exhibit significant heterogeneity and contribute to immune regulation through cytokine secretion and differentiation into dendritic cells and macrophages. Aberrant monocytes are associated with the prognosis of MPNs, particularly PMF. Furthermore, these altered monocytes play a critical role in the pathogenesis and progression of MPNs. This review aims to explore the heterogeneity of different monocyte subsets during homeostasis and focuses on the potential mechanisms by which monocytes contribute to the development and progression of MPNs.
Keywords: myeloproliferative neoplasms; monocytes; SLAMF7; Tie2 myeloproliferative neoplasms; monocytes; SLAMF7; Tie2

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MDPI and ACS Style

Li, X.; Xu, M.; Wang, Y. Monocyte Involvement in the Pathogenesis of Myeloproliferative Neoplasms. Int. J. Mol. Sci. 2025, 26, 6422. https://doi.org/10.3390/ijms26136422

AMA Style

Li X, Xu M, Wang Y. Monocyte Involvement in the Pathogenesis of Myeloproliferative Neoplasms. International Journal of Molecular Sciences. 2025; 26(13):6422. https://doi.org/10.3390/ijms26136422

Chicago/Turabian Style

Li, Xuedong, Mingli Xu, and Yingying Wang. 2025. "Monocyte Involvement in the Pathogenesis of Myeloproliferative Neoplasms" International Journal of Molecular Sciences 26, no. 13: 6422. https://doi.org/10.3390/ijms26136422

APA Style

Li, X., Xu, M., & Wang, Y. (2025). Monocyte Involvement in the Pathogenesis of Myeloproliferative Neoplasms. International Journal of Molecular Sciences, 26(13), 6422. https://doi.org/10.3390/ijms26136422

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