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Volume 24
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10.3390/ijms241612826
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Article

Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability

by
Barbara Flasz
1,
Amrendra K. Ajay
2,
Monika Tarnawska
1,
Agnieszka Babczyńska
1,
Łukasz Majchrzycki
3,
Andrzej Kędziorski
1,
Łukasz Napora-Rutkowski
4,
Ewa Świerczek
1 and
Maria Augustyniak
1,*
1
Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, 40-007 Katowice, Poland
2
Department of Medicine, Division of Renal Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
3
Center for Advanced Technology, Adam Mickiewicz University, 61-614 Poznań, Poland
4
Polish Academy of Sciences, Institute of Ichthyobiology and Aquaculture in Gołysz, 43-520 Chybie, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(16), 12826; https://doi.org/10.3390/ijms241612826
Submission received: 3 July 2023 / Revised: 3 August 2023 / Accepted: 13 August 2023 / Published: 15 August 2023
(This article belongs to the Special Issue Nanomaterials in Nanobiotechnology and Nanomedicine)
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Abstract

The use of nanoparticles like graphene oxide (GO) in nanocomposite industries is growing very fast. There is a strong concern that GO can enter the environment and become nanopollutatnt. Environmental pollutants’ exposure usually relates to low concentrations but may last for a long time and impact following generations. Attention should be paid to the effects of nanoparticles, especially on the DNA stability passed on to the offspring. We investigated the multigenerational effects on two strains (wild and long-lived) of house cricket intoxicated with low GO concentrations over five generations, followed by one recovery generation. Our investigation focused on oxidative stress parameters, specifically AP sites (apurinic/apyrimidinic sites) and 8-OHdG (8-hydroxy-2′-deoxyguanosine), and examined the global DNA methylation pattern. Five intoxicated generations were able to overcome the oxidative stress, showing that relatively low doses of GO have a moderate effect on the house cricket (8-OHdG and AP sites). The last recovery generation that experienced a transition from contaminated to uncontaminated food presented greater DNA damage. The pattern of DNA methylation was comparable in every generation, suggesting that other epigenetic mechanisms might be involved.
Keywords: graphene oxide; multigenerational effects; oxidative stress; DNA damage; DNA methylation; epigenetics; invertebrate; nanotoxicity; 8-OHdG; AP sites graphene oxide; multigenerational effects; oxidative stress; DNA damage; DNA methylation; epigenetics; invertebrate; nanotoxicity; 8-OHdG; AP sites

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MDPI and ACS Style

Flasz, B.; Ajay, A.K.; Tarnawska, M.; Babczyńska, A.; Majchrzycki, Ł.; Kędziorski, A.; Napora-Rutkowski, Ł.; Świerczek, E.; Augustyniak, M. Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability. Int. J. Mol. Sci. 2023, 24, 12826. https://doi.org/10.3390/ijms241612826

AMA Style

Flasz B, Ajay AK, Tarnawska M, Babczyńska A, Majchrzycki Ł, Kędziorski A, Napora-Rutkowski Ł, Świerczek E, Augustyniak M. Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability. International Journal of Molecular Sciences. 2023; 24(16):12826. https://doi.org/10.3390/ijms241612826

Chicago/Turabian Style

Flasz, Barbara, Amrendra K. Ajay, Monika Tarnawska, Agnieszka Babczyńska, Łukasz Majchrzycki, Andrzej Kędziorski, Łukasz Napora-Rutkowski, Ewa Świerczek, and Maria Augustyniak. 2023. "Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability" International Journal of Molecular Sciences 24, no. 16: 12826. https://doi.org/10.3390/ijms241612826

APA Style

Flasz, B., Ajay, A. K., Tarnawska, M., Babczyńska, A., Majchrzycki, Ł., Kędziorski, A., Napora-Rutkowski, Ł., Świerczek, E., & Augustyniak, M. (2023). Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability. International Journal of Molecular Sciences, 24(16), 12826. https://doi.org/10.3390/ijms241612826

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