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Article

CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS

by
Andrea Burgetova
1,
Petr Dusek
1,2,
Tomas Uher
2,
Manuela Vaneckova
1,
Martin Vejrazka
3,
Romana Burgetova
1,4,
Dana Horakova
2,
Barbora Srpova
2,
Marta Kalousova
3,
Libuse Noskova
3,
Katerina Levova
3,
Jan Krasensky
1 and
Lukas Lambert
1,*
1
Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 121 08 Prague, Czech Republic
2
Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 121 08 Prague, Czech Republic
3
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 121 08 Prague, Czech Republic
4
Department of Radiology, Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(12), 10048; https://doi.org/10.3390/ijms241210048
Submission received: 25 April 2023 / Revised: 27 May 2023 / Accepted: 8 June 2023 / Published: 12 June 2023
(This article belongs to the Special Issue Insights in Multiple Sclerosis (MS) and Neuroimmunology)
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Abstract

In this prospective longitudinal study, we quantified regional brain volume and susceptibility changes during the first two years after the diagnosis of multiple sclerosis (MS) and identified their association with cerebrospinal fluid (CSF) markers at baseline. Seventy patients underwent MRI (T1 and susceptibility weighted images processed to quantitative susceptibility maps, QSM) with neurological examination at the diagnosis and after two years. In CSF obtained at baseline, the levels of oxidative stress, products of lipid peroxidation, and neurofilaments light chain (NfL) were determined. Brain volumetry and QSM were compared with a group of 58 healthy controls. In MS patients, regional atrophy was identified in the striatum, thalamus, and substantia nigra. Magnetic susceptibility increased in the striatum, globus pallidus, and dentate and decreased in the thalamus. Compared to controls, MS patients developed greater atrophy of the thalamus, and a greater increase in susceptibility in the caudate, putamen, globus pallidus and a decrease in the thalamus. Of the multiple calculated correlations, only the decrease in brain parenchymal fraction, total white matter, and thalamic volume in MS patients negatively correlated with increased NfL in CSF. Additionally, negative correlation was found between QSM value in the substantia nigra and peroxiredoxin-2, and QSM value in the dentate and lipid peroxidation levels.
Keywords: multiple sclerosis; magnetic resonance imaging; cerebrospinal fluid; oxidative stress; iron; susceptibility multiple sclerosis; magnetic resonance imaging; cerebrospinal fluid; oxidative stress; iron; susceptibility

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MDPI and ACS Style

Burgetova, A.; Dusek, P.; Uher, T.; Vaneckova, M.; Vejrazka, M.; Burgetova, R.; Horakova, D.; Srpova, B.; Kalousova, M.; Noskova, L.; et al. CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS. Int. J. Mol. Sci. 2023, 24, 10048. https://doi.org/10.3390/ijms241210048

AMA Style

Burgetova A, Dusek P, Uher T, Vaneckova M, Vejrazka M, Burgetova R, Horakova D, Srpova B, Kalousova M, Noskova L, et al. CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS. International Journal of Molecular Sciences. 2023; 24(12):10048. https://doi.org/10.3390/ijms241210048

Chicago/Turabian Style

Burgetova, Andrea, Petr Dusek, Tomas Uher, Manuela Vaneckova, Martin Vejrazka, Romana Burgetova, Dana Horakova, Barbora Srpova, Marta Kalousova, Libuse Noskova, and et al. 2023. "CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS" International Journal of Molecular Sciences 24, no. 12: 10048. https://doi.org/10.3390/ijms241210048

APA Style

Burgetova, A., Dusek, P., Uher, T., Vaneckova, M., Vejrazka, M., Burgetova, R., Horakova, D., Srpova, B., Kalousova, M., Noskova, L., Levova, K., Krasensky, J., & Lambert, L. (2023). CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS. International Journal of Molecular Sciences, 24(12), 10048. https://doi.org/10.3390/ijms241210048

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