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Volume 23
Issue 19
10.3390/ijms231911169
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Review

Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells

by
Anastasiia D. Kurenkova
1,
Irina A. Romanova
2,
Pavel D. Kibirskiy
1,
Peter Timashev
1,2 and
Ekaterina V. Medvedeva
1,*
1
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
2
World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(19), 11169; https://doi.org/10.3390/ijms231911169
Submission received: 24 August 2022 / Revised: 17 September 2022 / Accepted: 19 September 2022 / Published: 22 September 2022
(This article belongs to the Special Issue Molecular and Tissue Engineering Approaches in Musculoskeletal Regenerative Medicine 4.0)
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Abstract

Damaged hyaline cartilage gradually decreases joint function and growing pain significantly reduces the quality of a patient’s life. The clinically approved procedure of autologous chondrocyte implantation (ACI) for treating knee cartilage lesions has several limits, including the absence of healthy articular cartilage tissues for cell isolation and difficulties related to the chondrocyte expansion in vitro. Today, various ACI modifications are being developed using autologous chondrocytes from alternative sources, such as the auricles, nose and ribs. Adult stem cells from different tissues are also of great interest due to their less traumatic material extraction and their innate abilities of active proliferation and chondrogenic differentiation. According to the different adult stem cell types and their origin, various strategies have been proposed for stem cell expansion and initiation of their chondrogenic differentiation. The current review presents the diversity in developing applied techniques based on autologous adult stem cell differentiation to hyaline cartilage tissue and targeted to articular cartilage damage therapy.
Keywords: adult stem cells; chondrogenic differentiation; tissue markers; osteoarthritis; articular cartilage; autologous chondrocytes; bone marrow; synovium; adipose tissue; dental pulp; periosteum; perichondrium; extracellular vesicles adult stem cells; chondrogenic differentiation; tissue markers; osteoarthritis; articular cartilage; autologous chondrocytes; bone marrow; synovium; adipose tissue; dental pulp; periosteum; perichondrium; extracellular vesicles

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MDPI and ACS Style

Kurenkova, A.D.; Romanova, I.A.; Kibirskiy, P.D.; Timashev, P.; Medvedeva, E.V. Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells. Int. J. Mol. Sci. 2022, 23, 11169. https://doi.org/10.3390/ijms231911169

AMA Style

Kurenkova AD, Romanova IA, Kibirskiy PD, Timashev P, Medvedeva EV. Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells. International Journal of Molecular Sciences. 2022; 23(19):11169. https://doi.org/10.3390/ijms231911169

Chicago/Turabian Style

Kurenkova, Anastasiia D., Irina A. Romanova, Pavel D. Kibirskiy, Peter Timashev, and Ekaterina V. Medvedeva. 2022. "Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells" International Journal of Molecular Sciences 23, no. 19: 11169. https://doi.org/10.3390/ijms231911169

APA Style

Kurenkova, A. D., Romanova, I. A., Kibirskiy, P. D., Timashev, P., & Medvedeva, E. V. (2022). Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells. International Journal of Molecular Sciences, 23(19), 11169. https://doi.org/10.3390/ijms231911169

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