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Review

The LPA3 Receptor: Regulation and Activation of Signaling Pathways

Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad de México CP 04510, Mexico
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Academic Editor: Alessandro Cannavo
Int. J. Mol. Sci. 2021, 22(13), 6704; https://doi.org/10.3390/ijms22136704
Received: 24 May 2021 / Revised: 8 June 2021 / Accepted: 12 June 2021 / Published: 23 June 2021
The lysophosphatidic acid 3 receptor (LPA3) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA3 receptor is a crucial element for defining its roles in health and disease. This review describes what is known about the signaling pathways activated in terms of its various actions. Next, we review knowledge on the structure of the LPA3 receptor, the domains found, and the roles that the latter might play in ligand recognition, signaling, and cellular localization. Currently, there is some information on the action of LPA3 in different cells and whole organisms, but very little is known about the regulation of its function. Areas in which there is a gap in our knowledge are indicated in order to further stimulate experimental work on this receptor and on other members of the LPA receptor family. We are convinced that knowledge on how this receptor is activated, the signaling pathways employed and how the receptor internalization and desensitization are controlled will help design new therapeutic interventions for treating diseases in which the LPA3 receptor is implicated. View Full-Text
Keywords: lysophosphatidic acid 3 receptor; LPA3; receptor phosphorylation; GRK; PKC; lysophosphatidic acid lysophosphatidic acid 3 receptor; LPA3; receptor phosphorylation; GRK; PKC; lysophosphatidic acid
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MDPI and ACS Style

Solís, K.H.; Romero-Ávila, M.T.; Guzmán-Silva, A.; García-Sáinz, J.A. The LPA3 Receptor: Regulation and Activation of Signaling Pathways. Int. J. Mol. Sci. 2021, 22, 6704. https://doi.org/10.3390/ijms22136704

AMA Style

Solís KH, Romero-Ávila MT, Guzmán-Silva A, García-Sáinz JA. The LPA3 Receptor: Regulation and Activation of Signaling Pathways. International Journal of Molecular Sciences. 2021; 22(13):6704. https://doi.org/10.3390/ijms22136704

Chicago/Turabian Style

Solís, Karina H., M. T. Romero-Ávila, Alejandro Guzmán-Silva, and J. A. García-Sáinz 2021. "The LPA3 Receptor: Regulation and Activation of Signaling Pathways" International Journal of Molecular Sciences 22, no. 13: 6704. https://doi.org/10.3390/ijms22136704

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