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Review

The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

by
Tatiana Wojciechowicz
1,
Maria Billert
1,
Mariami Jasaszwili
1,
Mathias Z. Strowski
2,3,
Krzysztof W. Nowak
1 and
Marek Skrzypski
1,*
1
Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, 35 Wołyńska St, 60-637 Poznań, Poland
2
Department of Hepatology and Gastroenterology, Charité-University Medicine Berlin, D-13353 Berlin, Germany
3
Department of Internal Medicine-Gastroenterology, Park-Klinik Weissensee, D-13086 Berlin, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(12), 6632; https://doi.org/10.3390/ijms22126632
Submission received: 29 April 2021 / Revised: 10 June 2021 / Accepted: 18 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue Neuropeptides in Food Intake Regulation)
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Abstract

Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous system (CNS) and in peripheral tissues. NPB is also present in the circulation. In the CNS, NPB modulates appetite, reproduction, pain, anxiety, and emotions. In the peripheral tissues, NPB controls secretion of adrenal hormones, pancreatic beta cells, and various functions of adipose tissue. Experimental downregulation of either NPB or NPBWR1 leads to adiposity. Here, we review the literature with regard to NPB-dependent control of metabolism and energy homeostasis.
Keywords: appetite; neuropeptide B; NPBWR1; NPRBWR2; metabolism; energy homeostasis appetite; neuropeptide B; NPBWR1; NPRBWR2; metabolism; energy homeostasis

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MDPI and ACS Style

Wojciechowicz, T.; Billert, M.; Jasaszwili, M.; Strowski, M.Z.; Nowak, K.W.; Skrzypski, M. The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis. Int. J. Mol. Sci. 2021, 22, 6632. https://doi.org/10.3390/ijms22126632

AMA Style

Wojciechowicz T, Billert M, Jasaszwili M, Strowski MZ, Nowak KW, Skrzypski M. The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis. International Journal of Molecular Sciences. 2021; 22(12):6632. https://doi.org/10.3390/ijms22126632

Chicago/Turabian Style

Wojciechowicz, Tatiana, Maria Billert, Mariami Jasaszwili, Mathias Z. Strowski, Krzysztof W. Nowak, and Marek Skrzypski. 2021. "The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis" International Journal of Molecular Sciences 22, no. 12: 6632. https://doi.org/10.3390/ijms22126632

APA Style

Wojciechowicz, T., Billert, M., Jasaszwili, M., Strowski, M. Z., Nowak, K. W., & Skrzypski, M. (2021). The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis. International Journal of Molecular Sciences, 22(12), 6632. https://doi.org/10.3390/ijms22126632

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