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Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function

Department of Haemostasis and Haemostatic Disorders, Chair of Biomedical Sciences, Medical University of Lodz, 92-215 Lodz, Poland
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Author to whom correspondence should be addressed.
These authors contributed equally to the publication.
Int. J. Mol. Sci. 2020, 21(21), 8334; https://doi.org/10.3390/ijms21218334
Received: 26 August 2020 / Revised: 23 October 2020 / Accepted: 4 November 2020 / Published: 6 November 2020
(This article belongs to the Special Issue Physiology of Platelets in Humans and Animals)
Platelet biology owes to intravital studies not only a better understanding of platelets’ role in primary hemostasis but also findings that platelets are important factors in inflammation and atherosclerosis. Researchers who enter the field of intravital platelet studies may be confused by the heterogeneity of experimental protocols utilized. On the one hand, there are a variety of stimuli used to activate platelet response, and on the other hand there are several approaches to measure the outcome of the activation. A number of possible combinations of activation factors with measurement approaches result in the aforementioned heterogeneity. The aim of this review is to present the most often used protocols in a systematic way depending on the stimulus used to activate platelets. By providing examples of studies performed with each of the protocols, we attempt to explain why a particular combination of stimuli and measurement method was applied to study a given aspect of platelet biology. View Full-Text
Keywords: platelets; intravital studies; thrombosis; atherosclerosis; inflammation; metastasis platelets; intravital studies; thrombosis; atherosclerosis; inflammation; metastasis
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MDPI and ACS Style

Polak, D.; Talar, M.; Watala, C.; Przygodzki, T. Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function. Int. J. Mol. Sci. 2020, 21, 8334. https://doi.org/10.3390/ijms21218334

AMA Style

Polak D, Talar M, Watala C, Przygodzki T. Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function. International Journal of Molecular Sciences. 2020; 21(21):8334. https://doi.org/10.3390/ijms21218334

Chicago/Turabian Style

Polak, Dawid; Talar, Marcin; Watala, Cezary; Przygodzki, Tomasz. 2020. "Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function" Int. J. Mol. Sci. 21, no. 21: 8334. https://doi.org/10.3390/ijms21218334

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