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Polyaniline Functionalized Graphene Nanoelectrodes for the Regeneration of PC12 Cells via Electrical Stimulation

Laboratory of Nanoscale Biosensing and Bioimaging, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, 270 Xueyuanxi Road, Wenzhou 325027, China
ARC Center of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 2013;
Received: 19 March 2019 / Revised: 17 April 2019 / Accepted: 19 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Graphene: Biological Applications)
PDF [1785 KB, uploaded 24 April 2019]


The regeneration of neurons is an important goal of neuroscience and clinical medicine. The electrical stimulation of cells is a promising technique to meet this goal. However, its efficiency highly depends on the electrochemical properties of the stimulation electrodes used. This work reports on the preparation and use of a highly electroactive and biocompatible nanoelectrode made from a novel polyaniline functionalized graphene composite. This nanocomposite was prepared using a facile and efficient polymerization-enhanced ball-milling method. It was used to stimulate the growth of PC12 cells under various electrical fields. The enhanced growth of axons and improved wound regeneration of PC12 cells were observed after this treatment, suggesting a promising strategy for neuro traumatology. View Full-Text
Keywords: polyaniline; graphene; neuroregeneration; PC12 cells; electrical stimulation polyaniline; graphene; neuroregeneration; PC12 cells; electrical stimulation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zheng, Z.; Huang, L.; Yan, L.; Yuan, F.; Wang, L.; Wang, K.; Lawson, T.; Lin, M.; Liu, Y. Polyaniline Functionalized Graphene Nanoelectrodes for the Regeneration of PC12 Cells via Electrical Stimulation. Int. J. Mol. Sci. 2019, 20, 2013.

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