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Int. J. Mol. Sci. 2019, 20(2), 324; https://doi.org/10.3390/ijms20020324

The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview

1,2,3,* and 1,2,4,*
1
Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
2
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
3
Institute of Clinical Chemistry, University Hospital Zurich, 8952 Schlieren, Switzerland
4
GLOBE Program Association (GLOBE-PA), 49418 Grandville, MI, USA
*
Authors to whom correspondence should be addressed.
Received: 5 December 2018 / Revised: 1 January 2019 / Accepted: 2 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Mechanisms of Inflammation in Degenerative Cardiovascular Conditions)
PDF [408 KB, uploaded 14 January 2019]   |   Review Reports

Abstract

Vascular smooth muscle cell (VSMC) proliferation plays a critical role in atherosclerosis. At the beginning of the pathologic process of atherosclerosis, irregular VSMC proliferation promotes plaque formation, but in advanced plaques VSMCs are beneficial, promoting the stability and preventing rupture of the fibrous cap. Recent studies have demonstrated that microRNAs (miRNAs) expressed in the vascular system are involved in the control of VSMC proliferation. This review summarizes recent findings on the miRNAs in the regulation of VSMC proliferation, including miRNAs that exhibit the inhibition or promotion of VSMC proliferation, and their targets mediating the regulation of VSMC proliferation. Up to now, most of the studies were performed only in cultured VSMC. While the modulation of miRNAs is emerging as a promising strategy for the regulation of VSMC proliferation, most of the effects of miRNAs and their targets in vivo require further investigation.
Keywords: miRNA; VSMC; proliferation; atherosclerosis; CVD; restenosis miRNA; VSMC; proliferation; atherosclerosis; CVD; restenosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wang, D.; Atanasov, A.G. The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview. Int. J. Mol. Sci. 2019, 20, 324.

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