Next Article in Journal
Fumaric Acids Directly Influence Gene Expression of Neuroprotective Factors in Rodent Microglia
Previous Article in Journal
Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells
Previous Article in Special Issue
Effect of Cyclic Stretch on Vascular Endothelial Cells and Abdominal Aortic Aneurysm (AAA): Role in the Inflammatory Response
Article Menu

Article Versions

Export Article

Open AccessReview
Int. J. Mol. Sci. 2019, 20(2), 324;

The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview

1,2,3,* and 1,2,4,*
Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
Institute of Clinical Chemistry, University Hospital Zurich, 8952 Schlieren, Switzerland
GLOBE Program Association (GLOBE-PA), 49418 Grandville, MI, USA
Authors to whom correspondence should be addressed.
Received: 5 December 2018 / Revised: 1 January 2019 / Accepted: 2 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Mechanisms of Inflammation in Degenerative Cardiovascular Conditions)
PDF [408 KB, uploaded 14 January 2019]   |   Review Reports


Vascular smooth muscle cell (VSMC) proliferation plays a critical role in atherosclerosis. At the beginning of the pathologic process of atherosclerosis, irregular VSMC proliferation promotes plaque formation, but in advanced plaques VSMCs are beneficial, promoting the stability and preventing rupture of the fibrous cap. Recent studies have demonstrated that microRNAs (miRNAs) expressed in the vascular system are involved in the control of VSMC proliferation. This review summarizes recent findings on the miRNAs in the regulation of VSMC proliferation, including miRNAs that exhibit the inhibition or promotion of VSMC proliferation, and their targets mediating the regulation of VSMC proliferation. Up to now, most of the studies were performed only in cultured VSMC. While the modulation of miRNAs is emerging as a promising strategy for the regulation of VSMC proliferation, most of the effects of miRNAs and their targets in vivo require further investigation.
Keywords: miRNA; VSMC; proliferation; atherosclerosis; CVD; restenosis miRNA; VSMC; proliferation; atherosclerosis; CVD; restenosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wang, D.; Atanasov, A.G. The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview. Int. J. Mol. Sci. 2019, 20, 324.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top