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Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer

1
School of Life Science, Northwestern Polytechnical University, Xi’an 710072, China
2
Research & Development Institute in Shenzhen, Northwestern Polytechnical University, Shenzhen 518057, China
3
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi’an 710072, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1545; https://doi.org/10.3390/ijms19051545
Received: 29 April 2018 / Revised: 16 May 2018 / Accepted: 17 May 2018 / Published: 22 May 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Iron is an essential element for the growth and proliferation of cells. Cellular iron uptake, storage, utilization and export are tightly regulated to maintain iron homeostasis. However, cellular iron metabolism pathways are disturbed in most cancer cells. To maintain rapid growth and proliferation, cancer cells acquire large amounts of iron by altering expression of iron metabolism- related proteins. In this paper, normal cellular iron metabolism and the alterations of iron metabolic pathways in cancer cells were summarized. Therapeutic strategies based on targeting the altered iron metabolism were also discussed and disrupting redox homeostasis by intracellular high levels of iron provides new insight for cancer therapy. Altered iron metabolism constitutes a promising therapeutic target for cancer therapy. View Full-Text
Keywords: iron metabolism; cancer; iron chelators; targeted therapy; redox homeostasis iron metabolism; cancer; iron chelators; targeted therapy; redox homeostasis
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MDPI and ACS Style

Zhou, L.; Zhao, B.; Zhang, L.; Wang, S.; Dong, D.; Lv, H.; Shang, P. Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer. Int. J. Mol. Sci. 2018, 19, 1545. https://doi.org/10.3390/ijms19051545

AMA Style

Zhou L, Zhao B, Zhang L, Wang S, Dong D, Lv H, Shang P. Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer. International Journal of Molecular Sciences. 2018; 19(5):1545. https://doi.org/10.3390/ijms19051545

Chicago/Turabian Style

Zhou, Liangfu, Bin Zhao, Lixiu Zhang, Shenghang Wang, Dandan Dong, Huanhuan Lv, and Peng Shang. 2018. "Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer" International Journal of Molecular Sciences 19, no. 5: 1545. https://doi.org/10.3390/ijms19051545

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