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Open AccessReview

Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita’ di Padova, Padova 35128, Italy
UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV—IRCCS, Padova 35128, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(9), 1904;
Received: 8 August 2017 / Revised: 30 August 2017 / Accepted: 1 September 2017 / Published: 5 September 2017
(This article belongs to the Special Issue Alterations to Signalling Pathways in Cancer Cells)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomic landscape of T-ALL has been the target of intense research. The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth. Notwithstanding, T-ALL patients are still treated with high-dose multiagent chemotherapy, potentially exposing these patients to considerable acute and long-term side effects. This review summarizes recent advances in our understanding of the signaling pathways relevant for the pathogenesis of T-ALL and the opportunities offered for targeted therapy. View Full-Text
Keywords: acute lymphoblastic leukemia; oncogenes; PI3K/AKT; targeted therapy acute lymphoblastic leukemia; oncogenes; PI3K/AKT; targeted therapy
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MDPI and ACS Style

Bongiovanni, D.; Saccomani, V.; Piovan, E. Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia. Int. J. Mol. Sci. 2017, 18, 1904.

AMA Style

Bongiovanni D, Saccomani V, Piovan E. Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences. 2017; 18(9):1904.

Chicago/Turabian Style

Bongiovanni, Deborah; Saccomani, Valentina; Piovan, Erich. 2017. "Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia" Int. J. Mol. Sci. 18, no. 9: 1904.

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