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Int. J. Mol. Sci. 2017, 18(7), 1547;

Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Sant’Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Interdepartmental Centre of Cancer Research “Giorgio Prodi”, University of Bologna, 40138 Bologna, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 30 April 2017 / Revised: 13 July 2017 / Accepted: 14 July 2017 / Published: 17 July 2017
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The onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive biomarkers, could lead to an improvement in the success rate of the proposed therapies. Although the process of biomarker selection and validation could be a long one, requiring solid statistics, large cohorts and multicentric validations, non-coding RNAs (ncRNAs) and in particular microRNAs, proved to be extremely promising in this field. Here we summarize some of the main studies correlating specific ncRNAs with sensitivity/resistance to chemotherapy, anti-VEGF therapy, anti-EGFR therapy and immunotherapy in colorectal cancer (CRC). View Full-Text
Keywords: colorectal cancer; non-coding RNA; microRNA; predictive biomarker colorectal cancer; non-coding RNA; microRNA; predictive biomarker

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Garajová, I.; Ferracin, M.; Porcellini, E.; Palloni, A.; Abbati, F.; Biasco, G.; Brandi, G. Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer. Int. J. Mol. Sci. 2017, 18, 1547.

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