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Open AccessArticle

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

1
Department of Clinical and Biological Sciences, University of Turin, AUO San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano, Italy
2
Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, 3200 Rue Sicotte, St-Hyacinthe, QC J2S 2M2, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(12), 2612; https://doi.org/10.3390/ijms18122612
Received: 7 November 2017 / Revised: 27 November 2017 / Accepted: 29 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Inflammaging and Oxidative Stress in Aging and Age-Related Disorders)
Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure and function that could contribute to asthma occurrence, and/or clinical presentation in the elderly. Also, naturally occurring equine asthma will be discussed as a possible model for studying the importance of oxidative stress and immun-aging/inflamm-aging in humans. View Full-Text
Keywords: asthma; elderly; neutrophil; oxidative stress; animal model; horse; aging asthma; elderly; neutrophil; oxidative stress; animal model; horse; aging
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MDPI and ACS Style

Bullone, M.; Lavoie, J.-P. The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma. Int. J. Mol. Sci. 2017, 18, 2612. https://doi.org/10.3390/ijms18122612

AMA Style

Bullone M, Lavoie J-P. The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma. International Journal of Molecular Sciences. 2017; 18(12):2612. https://doi.org/10.3390/ijms18122612

Chicago/Turabian Style

Bullone, Michela; Lavoie, Jean-Pierre. 2017. "The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma" Int. J. Mol. Sci. 18, no. 12: 2612. https://doi.org/10.3390/ijms18122612

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