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International Journal of Molecular Sciences, Volume 17, Issue 11

November 2016 - 189 articles

Cover Story: p53 is a multifunctional protein with high intrinsic disorder content. It homotetramerizes, interacts with myriads of binding partners, contains numerous posttranslational modifications, has several isoforms, and is commonly mutated in cancers. Therefore, p53 serves as an illustration of the protein structure–function continuum concept, where generation of multiple proteoforms by various means define the ability of a protein to have a multitude of structurally and functionally different states. View this paper.
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Articles (189)

  • Article
  • Open Access
72 Citations
16,456 Views
11 Pages

A Melting Curve-Based Multiplex RT-qPCR Assay for Simultaneous Detection of Four Human Coronaviruses

  • Zhenzhou Wan,
  • Ya’nan Zhang,
  • Zhixiang He,
  • Jia Liu,
  • Ke Lan,
  • Yihong Hu and
  • Chiyu Zhang

23 November 2016

Human coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1 are common respiratory viruses associated with acute respiratory infection. They have a global distribution. Rapid and accurate diagnosis of HCoV infection is important for the managem...

  • Article
  • Open Access
40 Citations
7,048 Views
14 Pages

Varietal Dependence of GLVs Accumulation and LOX-HPL Pathway Gene Expression in Four Vitis vinifera Wine Grapes

  • Xu Qian,
  • Xiao-Qing Xu,
  • Ke-Ji Yu,
  • Bao-Qing Zhu,
  • Yi-Bin Lan,
  • Chang-Qing Duan and
  • Qiu-Hong Pan

23 November 2016

Variety is one of the major factors influencing grape and wine aromatic characteristics. Green leaf volatiles (GLVs), derived from lipoxygenase-hydroperoxides lyase (LOX-HPL) pathway, are important components for the aromatic quality of grapes and wi...

  • Article
  • Open Access
3 Citations
5,912 Views
14 Pages

Age-Related Modulations of AQP4 and Caveolin-1 in the Hippocampus Predispose the Toxic Effect of Phoneutria nigriventer Spider Venom

  • Edilene S. Soares,
  • Leila M. Stávale,
  • Monique C. P. Mendonça,
  • Andressa Coope and
  • Maria Alice da Cruz-Höfling

23 November 2016

We have previously demonstrated that Phoneutria nigriventer venom (PNV) causes blood–brain barrier (BBB) breakdown, swelling of astrocytes end-feet and fluid permeation into brain interstitium in rats. Caveolae and water channels respond to BBB alter...

  • Article
  • Open Access
32 Citations
7,180 Views
14 Pages

Microarray Expression Profiling of Long Non-Coding RNAs Involved in Nasopharyngeal Carcinoma Metastasis

  • Xin Wen,
  • Xinran Tang,
  • Yingqin Li,
  • Xianyue Ren,
  • Qingmei He,
  • Xiaojing Yang,
  • Jian Zhang,
  • Yaqin Wang,
  • Jun Ma and
  • Na Liu

23 November 2016

Increasing evidence has demonstrated a significant role for long non-coding RNAs (lncRNAs) in tumorigenesis. However, their functions in nasopharyngeal carcinoma (NPC) metastasis remain largely unknown. In this study, a model comparing high and low m...

  • Review
  • Open Access
107 Citations
51,833 Views
20 Pages

d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology

  • Danilo De Gregorio,
  • Stefano Comai,
  • Luca Posa and
  • Gabriella Gobbi

23 November 2016

d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to und...

  • Article
  • Open Access
58 Citations
8,463 Views
22 Pages

23 November 2016

Glucosamine (GlcN) fulfills many of the requirements as an ideal component in scaffolds used in cartilage tissue engineering. The incorporation of GlcN in a gelatin/hyaluronic acid (GH) cryogel scaffold could provide biological cues in maintaining th...

  • Communication
  • Open Access
8 Citations
6,776 Views
10 Pages

Importance of Heat and Pressure for Solubilization of Recombinant Spider Silk Proteins in Aqueous Solution

  • Justin A. Jones,
  • Thomas I. Harris,
  • Paula F. Oliveira,
  • Brianne E. Bell,
  • Abdulrahman Alhabib and
  • Randolph V. Lewis

23 November 2016

The production of recombinant spider silk proteins continues to be a key area of interest for a number of research groups. Several key obstacles exist in their production as well as in their formulation into useable products. The original reported me...

  • Article
  • Open Access
27 Citations
5,993 Views
12 Pages

Intracranial Thrombus Morphology and Composition Undergoes Time-Dependent Changes in Acute Ischemic Stroke: A CT Densitometry Study

  • Slaven Pikija,
  • Jozef Magdic,
  • Vladimir Trkulja,
  • Peter Unterkreuter,
  • Johannes Sebastian Mutzenbach,
  • Helmut F. Novak,
  • Friedrich Weymayr,
  • Larissa Hauer and
  • Johann Sellner

23 November 2016

The aim of our study was to assess whether cerebral artery clots undergo time-dependent morphological and compositional changes in acute ischemic stroke. We performed a retrospective chart review of patients admitted within 5 h from symptom onset to...

  • Article
  • Open Access
29 Citations
8,203 Views
17 Pages

HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms

  • Salunya Tancharoen,
  • Satoshi Gando,
  • Shrestha Binita,
  • Tomoka Nagasato,
  • Kiyoshi Kikuchi,
  • Yuko Nawa,
  • Pornpen Dararat,
  • Mika Yamamoto,
  • Somphong Narkpinit and
  • Ikuro Maruyama

23 November 2016

High mobility group box 1 (HMGB1) is tightly connected to the process of tissue organization upon tissue injury. Here we show that HMGB1 controls epithelium and connective tissue regeneration both in vivo and in vitro during palatal wound healing. He...

  • Article
  • Open Access
57 Citations
7,749 Views
20 Pages

23 November 2016

Olive oils have been shown to be more resistant to oxidation than other vegetable fats, mainly due to their fatty acid (FA) profile which is rich in oleic acid and to their high content of antioxidants, principally phenols and tocopherols. This has s...

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Int. J. Mol. Sci. - ISSN 1422-0067