Special Issue "Emerging Non-Canonical Functions and Regulation of p53"
Deadline for manuscript submissions: closed (30 September 2016).
The tumor suppressor p53 gene is the most frequently mutated in human cancers, the majority of which are missense mutations. Mutant p53 is commonly stabilized in human cancers, causing unexpected oncogenic gain-of-function (GOF) phenotypes. The mechanisms underlying mutant p53 GOF and its stabilization have begun to emerge for the past several years. Accumulating evidence indicates that p53 is also involved in the regulation of various cellular activities, in addition to its well-known function as a regulator of cell cycle progression and Bcl-2 family protein-associated apoptosis. These include non-canonical mechanisms of cell death (calcium induced apoptosis, ferroptosis, necroptosis, autophagy, mitophagy), cell metabolism (glucose, lipid, nucleotide), immune regulation, chromosome integrity, and more. Learning these emerging functions of wild-type and mutant p53, as well as regulation of their stabilities or activities, would be crucial for deeper and more precise understanding of their roles in cell homeostasis and tumor development.
This Special Issue of the International Journal of Molecular Sciences, “Emerging Non-Canonical Functions and Regulation of p53”, will encompass a broad range of studies pertaining to recent findings in the p53 field.
Assoc. Prof. Dr. Tomoo Iwakuma
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- mutant p53
- non-canonical function
- chromosome instability
- immune regulation