Interleukin-17A Gene Expression in Morbidly Obese Women
AbstractData from recent studies conducted in rodent models and humans suggest that interleukin-17A (IL-17A) plays a role in the induction of inflammation in adipose tissue during obesity. The aim of this study was to assess the gene expression of IL-17A in adipose tissue of morbidly obese patients. We used RT-PCR to evaluate the expression of IL-17A and several adipo/cytokines in the visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) of 10 normal-weight control women (BMI < 25 kg/m2) and 30 morbidly obese women (MO, BMI > 40 kg/m2). We measured serum levels of IL-17A and adipo/cytokines in MO and normal weight women. IL-17A expression was significantly higher in VAT than in SAT in MO patients (p = 0.0127). It was very low in normal-weight controls in both VAT and SAT tissues. We found positive correlations between IL-17A and IL-6, lipocalin-2 and resistin in VAT of MO patients. The circulating level of IL-17A was higher in the normal-weight group than the MO patients (p = 0.032), and it was significantly related to adiponectin and TNFRII levels. In conclusion, IL-17A expression in VAT is increased in morbidly obese women, which suggests a link between obesity and innate immunity in low-grade chronic inflammation in morbidly obese women. View Full-Text
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Zapata-Gonzalez, F.; Auguet, T.; Aragonès, G.; Guiu-Jurado, E.; Berlanga, A.; Martinez, S.; Martí, A.; Sabench, F.; Hernandez, M.; Aguilar, C.; Sirvent, J.J.; Jorba, R.; Del Castillo, D.; Richart, C. Interleukin-17A Gene Expression in Morbidly Obese Women. Int. J. Mol. Sci. 2015, 16, 17469-17481.
Zapata-Gonzalez F, Auguet T, Aragonès G, Guiu-Jurado E, Berlanga A, Martinez S, Martí A, Sabench F, Hernandez M, Aguilar C, Sirvent JJ, Jorba R, Del Castillo D, Richart C. Interleukin-17A Gene Expression in Morbidly Obese Women. International Journal of Molecular Sciences. 2015; 16(8):17469-17481.Chicago/Turabian Style
Zapata-Gonzalez, Fernando; Auguet, Teresa; Aragonès, Gemma; Guiu-Jurado, Esther; Berlanga, Alba; Martinez, Salomé; Martí, Andreu; Sabench, Fátima; Hernandez, Mercé; Aguilar, Carmen; Sirvent, Joan J.; Jorba, Rosa; Del Castillo, Daniel; Richart, Cristóbal. 2015. "Interleukin-17A Gene Expression in Morbidly Obese Women." Int. J. Mol. Sci. 16, no. 8: 17469-17481.