Table of Contents
Int. J. Mol. Sci., Volume 16, Issue 8 (August 2015) , Pages 16710-20099
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Cover Story On insertion into the bacterial membrane, the polyphenol epicatechin gallate disrupts the cell wall [...] Read more. On insertion into the bacterial membrane, the polyphenol epicatechin gallate disrupts the cell wall biosynthetic machinery of multi-drug-resistant strains of Staphylococcus aureus, sensitizing the pathogen to beta-lactam antibiotics. Although the bacteria respond by altering the phospholipid composition of the membrane, the high degree of lipid asymmetry across the bilayer and the orthogonal mode of cell division are preserved. The compound could be useful in rescuing traditional antibiotics that have limited utility due to the evolution of antibiotic resistance. View the article