Next Article in Journal
Atherosclerotic Calcification Detection: A Comparative Study of Carotid Ultrasound and Cone Beam CT
Next Article in Special Issue
Mitochondrial Malfunctioning, Proteasome Arrest and Apoptosis in Cancer Cells by Focused Intracellular Generation of Oxygen Radicals
Previous Article in Journal
Resolving Intra- and Inter-Molecular Structure with Non-Contact Atomic Force Microscopy
Previous Article in Special Issue
More Adventures in Photodynamic Therapy
Open AccessArticle

Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy

1
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
2
Department of Cell Biology and Immunology, Wageningen University, 6709 PG Wageningen, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Michael R. Hamblin and Ying-Ying Huang
Int. J. Mol. Sci. 2015, 16(8), 19960-19977; https://doi.org/10.3390/ijms160819960
Received: 15 July 2015 / Revised: 13 August 2015 / Accepted: 17 August 2015 / Published: 21 August 2015
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
Although photodynamic therapy (PDT) yields very good outcomes in numerous types of superficial solid cancers, some tumors respond suboptimally to PDT. Novel treatment strategies are therefore needed to enhance the efficacy in these therapy-resistant tumors. One of these strategies is to combine PDT with inhibitors of PDT-induced survival pathways. In this respect, the transcription factor nuclear factor κB (NF-κB) has been identified as a potential pharmacological target, albeit inhibition of NF-κB may concurrently dampen the subsequent anti-tumor immune response required for complete tumor eradication and abscopal effects. In contrast to these postulations, this study demonstrated that siRNA knockdown of NF-κB in murine breast carcinoma (EMT-6) cells increased survival signaling in these cells and exacerbated the inflammatory response in murine RAW 264.7 macrophages. These results suggest a pro-death and immunosuppressive role of NF-κB in PDT-treated cells that concurs with a hyperstimulated immune response in innate immune cells. View Full-Text
Keywords: phototherapy; inflammation; anti-tumor immunity; siRNA; interleukin-6; tumor necrosis factor alpha; monocyte chemotactic protein 1 interleukin-10; interleukin-12p70; interferon gamma phototherapy; inflammation; anti-tumor immunity; siRNA; interleukin-6; tumor necrosis factor alpha; monocyte chemotactic protein 1 interleukin-10; interleukin-12p70; interferon gamma
Show Figures

Figure 1

MDPI and ACS Style

Broekgaarden, M.; Kos, M.; Jurg, F.A.; Van Beek, A.A.; Van Gulik, T.M.; Heger, M. Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy. Int. J. Mol. Sci. 2015, 16, 19960-19977.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop