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Int. J. Mol. Sci. 2015, 16(6), 13973-13988;

Adsorption of Silver Nanoparticles onto Different Surface Structures of Chitin/Chitosan and Correlations with Antimicrobial Activities

Research Institute, National Defense Medical College, Saitama 359-1324, Japan
Kobe VN Beef Corporation, Bao Loc City 670000, Vietnam
Department of Applied Chemistry and Chemical Engineering National Institute of Technology, Toyama College, Toyama 939-8630, Japan
Author to whom correspondence should be addressed.
Academic Editors: Hitoshi Sashiwa and Shinsuke Ifuku
Received: 9 May 2015 / Revised: 12 June 2015 / Accepted: 12 June 2015 / Published: 18 June 2015
(This article belongs to the Special Issue Chitins 2015)
Full-Text   |   PDF [3070 KB, uploaded 18 June 2015]   |  


Size-controlled spherical silver nanoparticles (Ag NPs) can be simply prepared by autoclaving mixtures of glass powder containing silver with glucose. Moreover, chitins with varying degrees of deacetylation (DDAc < 30%) and chitosan powders and sheets (DDAc > 75%) with varying surface structure properties have been evaluated as Ag NP carriers. Chitin/chitosan-Ag NP composites in powder or sheet form were prepared by mixing Ag NP suspensions with each of the chitin/chitosan-based material at pH 7.3, leading to homogenous dispersion and stable adsorption of Ag NPs onto chitin carriers with nanoscale fiber-like surface structures, and chitosan carriers with nanoscale porous surface structures. Although these chitins exhibited mild antiviral, bactericidal, and antifungal activities, chitin powders with flat/smooth film-like surface structures had limited antimicrobial activities and Ag NP adsorption. The antimicrobial activities of chitin/chitosan-Ag NP composites increased with increasing amounts of adsorbed Ag NPs, suggesting that the surface structures of chitin/chitosan carriers strongly influence adsorption of Ag NPs and antimicrobial activities. These observations indicate that chitin/chitosan-Ag NPs with nanoscale surface structures have potential as antimicrobial biomaterials and anti-infectious wound dressings. View Full-Text
Keywords: silver nanoparticles; chitin; chitosan; surface structure; antimicrobial activity silver nanoparticles; chitin; chitosan; surface structure; antimicrobial activity

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Ishihara, M.; Nguyen, V.Q.; Mori, Y.; Nakamura, S.; Hattori, H. Adsorption of Silver Nanoparticles onto Different Surface Structures of Chitin/Chitosan and Correlations with Antimicrobial Activities. Int. J. Mol. Sci. 2015, 16, 13973-13988.

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