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Open AccessReview

Lipidomics by Supercritical Fluid Chromatography

CNRS, Institut de Chimie des Substances Naturelles, UPR2301, Université Paris-Sud, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
Institut Mondor de Recherche Biomédicale, INSERM, U955 (eq. 21), Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France
Université Paris-Est Créteil Val-de-Marne, 94010 Créteil, France
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2015, 16(6), 13868-13884;
Received: 20 March 2015 / Revised: 12 May 2015 / Accepted: 28 May 2015 / Published: 17 June 2015
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics)
This review enlightens the role of supercritical fluid chromatography (SFC) in the field of lipid analysis. SFC has been popular in the late 1980s and 1990s before almost disappearing due to the commercial success of liquid chromatography (LC). It is only 20 years later that a regain of interest appeared when new commercial instruments were introduced. As SFC is fully compatible with the injection of extracts in pure organic solvent, this technique is perfectly suitable for lipid analysis and can be coupled with either highly universal (UV or evaporative light scattering) or highly specific (mass spectrometry) detection methods. A short history of the use of supercritical fluids as mobile phase for the separation oflipids will be introduced first. Then, the advantages and drawbacks of SFC are discussed for each class of lipids (fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, prenols, polyketides) defined by the LIPID MAPS consortium. View Full-Text
Keywords: supercritical fluid chromatography; mass spectrometry; lipid supercritical fluid chromatography; mass spectrometry; lipid
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Laboureur, L.; Ollero, M.; Touboul, D. Lipidomics by Supercritical Fluid Chromatography. Int. J. Mol. Sci. 2015, 16, 13868-13884.

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