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Int. J. Mol. Sci. 2015, 16(6), 14086-14097;

Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan
Department of Gastroenterology and Hepatology, Nissay Hospital, Itachibori 6-3-8, Nishi-ku, Osaka 550-0012, Japan
Department of Hepatology and Infectious Diseases, the Second Affiliated Hospital, Shantou University Medical College, No. 69, Dongxiabei, Jinping, Shantou 515041, China
Author to whom correspondence should be addressed.
Academic Editor: Tatsuo Kanda
Received: 25 May 2015 / Revised: 11 June 2015 / Accepted: 17 June 2015 / Published: 19 June 2015
(This article belongs to the Special Issue Viral Hepatitis Research)
Full-Text   |   PDF [854 KB, uploaded 19 June 2015]   |  


The development of hepatocellular carcinoma (HCC) is an important complication of viral infection induced by hepatitis virus C, and our major research theme is to identify a new growth factor related to the progression of HCC. HDGF (hepatoma-derived growth factor) is a novel growth factor that belongs to a new gene family. HDGF was initially purified from the conditioned medium of a hepatoma cell line. HDGF promotes cellular proliferation as a DNA binding nuclear factor and a secreted protein acting via a receptor-mediated pathway. HDGF is a unique multi-functional protein that can function as a growth factor, angiogenic factor and anti-apoptotic factor and it participates in the development and progression of various malignant diseases. The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC. Furthermore, the overexpression of HDGF promotes the proliferation of HCC cells, while a reduction in the HDGF expression inhibits the proliferation of HCC cells. This article provides an overview of the characteristics of HDGF and describes the potential role of HDGF as a growth-promoting factor for HCC. View Full-Text
Keywords: hepatoma-derived growth factor; hepatocellular carcinoma; angiogenesis; apoptosis hepatoma-derived growth factor; hepatocellular carcinoma; angiogenesis; apoptosis

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Enomoto, H.; Nakamura, H.; Liu, W.; Nishiguchi, S. Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma. Int. J. Mol. Sci. 2015, 16, 14086-14097.

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