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Mass Spectrometry-Based N-Glycomics of Colorectal Cancer

Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, NSW 2109, Australia
Department of Biomedical Sciences, Macquarie University, North Ryde, NSW 2109, Australia
Author to whom correspondence should be addressed.
Academic Editor: Patricia Berninsone
Int. J. Mol. Sci. 2015, 16(12), 29278-29304;
Received: 30 October 2015 / Revised: 23 November 2015 / Accepted: 1 December 2015 / Published: 9 December 2015
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
PDF [7108 KB, uploaded 10 December 2015]


Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding of the CRC pathology is warranted to gain insights into the underlying molecular and cellular mechanisms of the disease. Altered protein glycosylation patterns are associated with most diseases including malignant transformation. Recent advances in mass spectrometry and bioinformatics have accelerated glycomics research and present a new paradigm for cancer biomarker discovery. Mass spectrometry (MS)-based glycoproteomics and glycomics, therefore, hold considerable promise to improve the discovery of novel biomarkers with utility in disease diagnosis and therapy. This review focuses on the emerging field of glycomics to present a comprehensive review of advances in technologies and their application in studies aimed at discovering novel glycan-based biomarkers. We will also discuss some of the challenges associated with using glycans as biomarkers. View Full-Text
Keywords: cancer; colorectal cancer; glycosylation; glycome; N-glycomics cancer; colorectal cancer; glycosylation; glycome; N-glycomics

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sethi, M.K.; Fanayan, S. Mass Spectrometry-Based N-Glycomics of Colorectal Cancer. Int. J. Mol. Sci. 2015, 16, 29278-29304.

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