Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome
1
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
2
Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, China
3
Centre for Microbial Genomics and Proteomics, The Chinese University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick C. Y. Woo
Int. J. Mol. Sci. 2015, 16(11), 26263-26279; https://doi.org/10.3390/ijms161125957
Received: 11 July 2015
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Revised: 10 October 2015
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Accepted: 26 October 2015
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Published: 3 November 2015
(This article belongs to the Special Issue Microbial Genomics and Metabolomics)
Microbes have co-evolved with human beings for millions of years. They play a very important role in maintaining the health of the host. With the advancement in next generation sequencing technology, the microbiome profiling in the host can be obtained under different circumstances. This review focuses on the current knowledge of the alteration of complex microbial communities upon the infection of different pathogens, such as human immunodeficiency virus, hepatitis B virus, influenza virus, and Mycobacterium tuberculosis, at different body sites. It is believed that the increased understanding of the correlation between infectious disease and the alteration of the microbiome can contribute to better management of disease progression in the future. However, future studies may need to be more integrative so as to establish the exact causality of diseases by analyzing the correlation between microorganisms within the human host and the pathogenesis of infectious diseases.
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Keywords:
microbiome; metagenomics; next generation sequencing; infectious disease; HIV; HBV; influenza; tuberculosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Zhang, Y.; Lun, C.-Y.; Tsui, S.K.-W. Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome. Int. J. Mol. Sci. 2015, 16, 26263-26279. https://doi.org/10.3390/ijms161125957
AMA Style
Zhang Y, Lun C-Y, Tsui SK-W. Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome. International Journal of Molecular Sciences. 2015; 16(11):26263-26279. https://doi.org/10.3390/ijms161125957
Chicago/Turabian StyleZhang, Yinfeng, Cheuk-Yin Lun, and Stephen K.-W. Tsui. 2015. "Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome" International Journal of Molecular Sciences 16, no. 11: 26263-26279. https://doi.org/10.3390/ijms161125957
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