Int. J. Mol. Sci., Volume 16, Issue 10 (October 2015) – 145 articles , Pages 23127-25933
Cover Story: ESI mass spectrometry studies have made enormous contributions with macromolecules and their complexes. Nucleic acids are attractive therapeutic targets for compounds to modulate genetic processes and we have prepared several compound classes to target DNA. Screening for ligand–DNA complexes can prove daunting but a competitive mass spectrometric binding assay can help rapidly identify compounds with DNA sequence specificity. This powerful assay provides stoichiometry, binding mode and relative binding affinity and helps form rationally designed compounds with therapeutic potential. View this article.
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