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Int. J. Mol. Sci. 2015, 16(10), 25552-25559;

Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients

Post-Graduation Program, Hepatology at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre 90.050-170, Brasil
Centro de Tratamento da Obesidade (CTO), Hospital Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 92.010-300, Brasil
Author to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Received: 15 August 2015 / Revised: 23 September 2015 / Accepted: 14 October 2015 / Published: 23 October 2015
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
Full-Text   |   PDF [671 KB, uploaded 23 October 2015]


The aim was to investigate the prevalence of non-alcoholic steatohepatitis (NASH) and risk factors for hepatic fibrosis in morbidly obese patients submitted to bariatric surgery. This retrospective study recruited all patients submitted to bariatric surgery from January 2007 to December 2012 at a reference attendance center of Southern Brazil. Clinical and biochemical data were studied as a function of the histological findings of liver biopsies done during the surgery. Steatosis was present in 226 (90.4%) and NASH in 176 (70.4%) cases. The diagnosis of cirrhosis was established in four cases (1.6%) and fibrosis in 108 (43.2%). Risk factors associated with NASH at multivariate analysis were alanine aminotransferase (ALT) >1.5 times the upper limit of normal (ULN); glucose ≥ 126 mg/dL and triglycerides ≥ 150 mg/dL. All patients with ALT ≥1.5 times the ULN had NASH. When the presence of fibrosis was analyzed, ALT > 1.5 times the ULN and triglycerides ≥ 150 mg/dL were risk factors, furthermore, there was an increase of 1% in the prevalence of fibrosis for each year of age increase. Not only steatosis, but NASH is a frequent finding in MO patients. In the present study, ALT ≥ 1.5 times the ULN identifies all patients with NASH, this finding needs to be further validated in other studies. Moreover, the presence of fibrosis was associated with ALT, triglycerides and age, identifying a subset of patients with more severe disease. View Full-Text
Keywords: NAFLD; NASH; morbidly obese; liver fibrosis NAFLD; NASH; morbidly obese; liver fibrosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Losekann, A.; Weston, A.C.; de Mattos, A.A.; Tovo, C.V.; de Carli, L.A.; Espindola, M.B.; Pioner, S.R.; Coral, G.P. Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients. Int. J. Mol. Sci. 2015, 16, 25552-25559.

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