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Int. J. Mol. Sci. 2015, 16(10), 25392-25432;

Changes in Regenerative Capacity through Lifespan

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK
Academic Editor: Francesc Cebrià
Received: 1 September 2015 / Revised: 30 September 2015 / Accepted: 30 September 2015 / Published: 23 October 2015
(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
PDF [1894 KB, uploaded 23 October 2015]


Most organisms experience changes in regenerative abilities through their lifespan. During aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that results in tissue degeneration, malfunction and pathology. The mechanisms responsible for this decay are both cell intrinsic, such as cellular senescence, as well as cell-extrinsic, such as changes in the regenerative environment. Understanding how these mechanisms impact on regenerative processes is essential to devise therapeutic approaches to improve tissue regeneration and extend healthspan. This review offers an overview of how regenerative abilities change through lifespan in various organisms, the factors that underlie such changes and the avenues for therapeutic intervention. It focuses on established models of mammalian regeneration as well as on models in which regenerative abilities do not decline with age, as these can deliver valuable insights for our understanding of the interplay between regeneration and aging. View Full-Text
Keywords: aging; regeneration; senescence; stem cells; reprogramming; newt; axolotl; zebrafish; planaria aging; regeneration; senescence; stem cells; reprogramming; newt; axolotl; zebrafish; planaria

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yun, M.H. Changes in Regenerative Capacity through Lifespan. Int. J. Mol. Sci. 2015, 16, 25392-25432.

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