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Open AccessArticle

The Association of Il28b Genotype with the Histological Features of Chronic Hepatitis C Is HCV Genotype Dependent

1
Division of Gastroenterology and Hepatology, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan 20100, Italy
2
INGM, Istituto Nazionale Genetica Molecolare Milano, Milan 20100, Italy
3
Division of Hepatology, Ospedale San Giuseppe IRCCS Multimedica, Università degli Studi di Milano, Milan 20100, Italy
4
Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
5
Kirby Institute for Infection and Immunity in Society, University of South Wales, Kensington 2033, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(5), 7213-7224; https://doi.org/10.3390/ijms15057213
Received: 25 February 2014 / Revised: 26 March 2014 / Accepted: 28 March 2014 / Published: 25 April 2014
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as <5% or ≥5%. IL28B was typed by Taqman Single Nucleotide Polymorphism (SNP) genotyping assay. HCV genotype was 1 in 151 (45%), 2 in 99 (30%), 3 in 50 (15%) and 4 in 35 (10%) patients. IL28B genotype was CC in 117 (34%), CT in 166 (49%) and TT in 52 (15%). At univariate analysis, the IL28B CC genotype was associated with severe portal inflammation in HCV-1 patients (CC vs. CT/TT: 86% vs. 63%, p = 0.005), severe lobular inflammation in HCV-2 patients (CC vs. CT/TT: 44% vs. 23%, p = 0.03), and less fatty infiltration in HCV-1 patients (CC vs. CT/TT: 72% vs. 51%, p = 0.02). Despite the lack of any association between IL28B and fibrosis stage, in HCV-3 patients IL28B CC correlated with METAVIR F3-F4 (CC vs. CT/TT: 74% vs. 26%, p = 0.05). At multivariate analysis, the genotype CC remained associated with severe portal inflammation in HCV-1, only (Odds Ratio (OR): 95% Confidence Interval (CI): 3.24 (1.23–8.51)). IL28B genotype is associated with the histological features of chronic hepatitis C in a HCV genotype dependent manner, with CC genotype being independently associated with severe portal inflammation. View Full-Text
Keywords: interleukin 28B (IL28B) polymorphism; hepatitis C virus (HCV); histology; liver biopsy; fibrosis; necroinflammation; steatosis; natural history interleukin 28B (IL28B) polymorphism; hepatitis C virus (HCV); histology; liver biopsy; fibrosis; necroinflammation; steatosis; natural history
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MDPI and ACS Style

D'Ambrosio, R.; Aghemo, A.; De Francesco, R.; Rumi, M.G.; Galmozzi, E.; De Nicola, S.; Cheroni, C.; Clark, P.J.; Ronchi, G.; Lampertico, P.; Colombo, M. The Association of Il28b Genotype with the Histological Features of Chronic Hepatitis C Is HCV Genotype Dependent. Int. J. Mol. Sci. 2014, 15, 7213-7224. https://doi.org/10.3390/ijms15057213

AMA Style

D'Ambrosio R, Aghemo A, De Francesco R, Rumi MG, Galmozzi E, De Nicola S, Cheroni C, Clark PJ, Ronchi G, Lampertico P, Colombo M. The Association of Il28b Genotype with the Histological Features of Chronic Hepatitis C Is HCV Genotype Dependent. International Journal of Molecular Sciences. 2014; 15(5):7213-7224. https://doi.org/10.3390/ijms15057213

Chicago/Turabian Style

D'Ambrosio, Roberta; Aghemo, Alessio; De Francesco, Raffaele; Rumi, Maria G.; Galmozzi, Enrico; De Nicola, Stella; Cheroni, Cristina; Clark, Paul J.; Ronchi, Guido; Lampertico, Pietro; Colombo, Massimo. 2014. "The Association of Il28b Genotype with the Histological Features of Chronic Hepatitis C Is HCV Genotype Dependent" Int. J. Mol. Sci. 15, no. 5: 7213-7224. https://doi.org/10.3390/ijms15057213

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