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Int. J. Mol. Sci. 2014, 15(4), 5277-5291;

Antibacterial Activity of New Oxazolidin-2-One Analogues in Methicillin-Resistant Staphylococcus aureus Strains

Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, Mexico
Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California 22000, Mexico
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa 80010, Mexico
Authors to whom correspondence should be addressed.
Received: 30 November 2013 / Revised: 12 March 2014 / Accepted: 17 March 2014 / Published: 26 March 2014
(This article belongs to the Section Biochemistry)
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Staphylococcus aureus is one of the most common causes of nosocomial infections. The purpose of this study was the synthesis and in vitro evaluation of antimicrobial activity of 10 new 3-oxazolidin-2-one analogues on 12 methicillin resistant S. aureus (MRSA) clinical isolates. S. aureus confirmation was achieved via catalase and coagulase test. Molecular characterization of MRSA was performed by amplification of the mecA gene. Antimicrobial susceptibility was evaluated via the Kirby-Bauer disc diffusion susceptibility test protocol, using commonly applied antibiotics and the oxazolidinone analogues. Only (R)-5-((S)-1-dibenzylaminoethyl)-1,3-oxazolidin-2-one (7a) exhibited antibacterial activity at 6.6 μg. These results, allow us to infer that molecules such as 7a can be potentially used to treat infections caused by MRSA strains. View Full-Text
Keywords: Staphylococcusaureus; methicillin; oxazolidin-2-ones; antibacterial Staphylococcusaureus; methicillin; oxazolidin-2-ones; antibacterial

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Córdova-Guerrero, J.; Hernández-Guevara, E.; Ramírez-Zatarain, S.; Núñez-Bautista, M.; Ochoa-Terán, A.; Muñiz-Salazar, R.; Montes-Ávila, J.; López-Angulo, G.; Paniagua-Michel, A.; Torres, G.A.N. Antibacterial Activity of New Oxazolidin-2-One Analogues in Methicillin-Resistant Staphylococcus aureus Strains. Int. J. Mol. Sci. 2014, 15, 5277-5291.

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