Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride
Abstract
:Introduction:
Results and Discussion:
Cyclized Product | Dehydrating Agent: POCl3 % Yield / Conditions | Dehydrating Agent: P2O3Cl4 % Yield / Conditions | ||
Anthraquinone | 53 | reflux 3 hrs | 65 | Reflux in CH3NO2, 2.5 hrs |
Anthrone | 90 | reflux 30 min | Quant * | Room temperature, 30 min. |
2-Methoxyanthraquinone | 43 | reflux 1.5 hrs | 75 | Warm at 40°, 2 hrs |
2-Chloroanthraquinone | 20 | reflux 3 hrs | 20 | Heat at 150°, 1 hr |
1-Tetralone | 70 | room temp, 2 days | 90 | Room temperature, 30 min. |
1-Indanone | 18 | reflux 5 min | 20 | Warm at 35°C, 30 min., |
2-Coumaranone | 90 | reflux 5 min. | Quant* | Warm at 35°C, 20 min., |
Conclusions
Experimental
General
Synthetic procedures
Spectral Data
Acknowledgements
References
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El-Sayrafi, S.; Rayyan, S. Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride. Molecules 2001, 6, 279-286. https://doi.org/10.3390/60300279
El-Sayrafi S, Rayyan S. Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride. Molecules. 2001; 6(3):279-286. https://doi.org/10.3390/60300279
Chicago/Turabian StyleEl-Sayrafi, Sami, and Saleh Rayyan. 2001. "Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride" Molecules 6, no. 3: 279-286. https://doi.org/10.3390/60300279