Molecules, Volume 6, Issue 3

Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic...

The title organometallic compound, potentially important synthetic intermediate, was prepared regio- and stereospecifically from b-himachalene ((4aR)-3,5,5,9-Tetramethyl-2,4a,5,6,7,8-hexahydro-1H-benzocycloheptene), essentiel component of cedrus atla...

As part of a research programme targeting novel indole-based molecules as potential cannabinoid agonists we synthesised [5-hydroxy-1-(2-morpholinoethyl)-1H-indol-3-yl](4-methoxyphenyl)methanone [1-4].[...]

As part of a research programme targeting novel molecules as potential anti-inflammatory agents we synthesised 3-Chloro-5-methoxy-1-benzo[b]thiophene-2-sulphonylamide base on the reported anti-inflammatory activity of the structurally related molecul...

As part of a research programme targeting novel indole-like molecules as potential cannabinoid agonists [1-4] we synthesised N-(2-ethylmorpholino)-3-bis-keto(1-naphthyl)oxindole.[...]

As part of a research programme targeting novel indole-like molecules as potential cannabinoid agonists [1-4] we synthesised N-(2-ethylmorpholino)-3-bis keto(1-naphthyl) oxindole.[...]

As part of a research programme targeting novel indole-like molecules as potential cannabinoid agonists [1-4] we synthesised N-(2-ethylmorpholino)-3-bis-ketothiene.[...]

As part of a research programme targeting novel indole-like molecules as potential cannabinoid agonists [1-4] we synthesised methyl 3-(2-(N-morpholino)ethyl-5-methoxybenzofuran-2-carboxylate.[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

The general part of the experimental section [1] has been presented elsewhere. Boron trifluoride diethyl etherate (313 mg, 2.21 mmol) was added dropwise to a solution of oxime 1 (100 mg, 0.735 mmol) in toluene (8 mL) at -78^oC under nitrogen and the m...

The general part of the experimental section [1] has been presented elsewhere.[...]

As part of a research programme targeting novel molecules as potential anti-inflammatory agents we synthesised methyl 3-hydroxythieno[2,3-b]pyridine-2-carboxylate based on the reported anti-inflammatory activity of the structurally related molecule 3...

For this synthesis, we propose a modification of the reaction procedure described in [1].[...]

A key intermediate in the synthesis of extended bipyridine ligands [1] is 4-hydroxymethylene-4-methyl-2,2-bipyridine (3), because the hydroxy group is readily converted into a variety of other chemical moieties, such as leaving or carbonyl groups.[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

Quinoline and its derivatives have been widely used as metal ion chelating agents, metal extracting agents, corrosive inhibitors and they often show biological activity.[...]

Diorganotin dihalide complexes with bidentate nitrogen ligands exhibit some pharmaceutical activities such as antitumour activity, antiviral activity and anti-microbiological activity[1-3], we have synthesized some diorganotin dihalide complexes with...

Diorganotin dihalide complexes with bidentate nitrogen ligands exhibit some pharmaceutical activities such as antitumour activity, antiviral activity and anti-microbiological activity[1-3], we have synthesized some diorganotin dihalide and dipseudoha...

A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the trea...

7-(1-Acetoxymethylidene)benzonorbornadiene 3, prepared in one step by the addition of benzyne to 6-acetoxyfulvene 2, is hydrolysed in acid solution to form a 3:2-epimeric mixture of syn- and anti- 7-formylbenzonorbornadienes 4 and 5, respectively; th...

Synthesis of the title compound,1-(2'-O-methyl-ß-D-ribofuranosyl)-1H-imidazo-[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in four steps, starting from methyl 1-(ß-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hyd...

The ZnBr₂ complex of the title compound has been studied by both structural and theoretical methods. Similar reactivities have been observed for the nitrone alone and the complex in 1,3-dipolar cycloadditions and nucleophilic additions.

Association constants of complexes of a new class of cyclodextrin alkyl derivatives - randomly susbstituted tert-butyl derivatives (TB-CDs) with complete set of mono-halobenzoic acids and acridine derivatives were measured using capillary electrophor...

Methods for the synthesis of N¹, N⁸-bis(9-acridinyl)-N⁴-(4-hydroxybenzyl)-spermidine and N¹, N⁷-(hydroxybenzyl)-bis-(3-aminopropyl)amine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4-chlorobutyronitr...

The cyclic hydroboration of 2,7-dimethyl-2,6-octadiene (6) was studied. It was found that the stereochemical outcome of the reaction was dependent upon the solvent, temperature, time and the nature of the borane reagent. Pure racemic trans-2,5-diisop...

N-Bromosulphonamides, synthesized via direct bromination of sulphonamides, react with several types of arene substrates in the presence of KSCN to afford aryl thiocyanates. The method appears to be generally applicable to benzenoid substrates with a...

The Cu-catalyzed intramolecular CH insertion of phenyliodonium ylide 5b has been investigated at 0° C in the presence of several chiral ligands. Enantioselectivities vary in the range of 38–72 %, and are higher than those resulting from reaction of t...

A number of novel triazinoquinazolinones (5b,c and 8), triazepinoquinazolinones(5a, 6b, 7 and 9) and triazocinoquinazolinones (6a and 10) were obtained via nucleophilic interaction of 3-aminoquinazolinone derivatives 3 with different reagents.