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Molecules, Volume 30, Issue 3

February-1 2025 - 326 articles

Cover Story: This study presents the complete 1H and 13C NMR assignments for borneol, isoborneol, and their protected derivatives in multiple solvents. The protection of the hydroxyl groups induced distinct downfield/upfield chemical shift changes in the protons and carbons on the bicyclic rings, enabling unambiguous structural assignments. The experimental chemical shifts showed strong correlations with those calculated by the density functional theory (DFT). The iso-chemical shielding surface (ICSS) analysis further quantified the anisotropic effects of the benzene rings introduced by the protecting groups in the hydroxyl positions, revealing substituent-dependent shielding patterns. The systematic approach combining experimental NMR, computational modeling, and ICSS visualization provides powerful tools for the structural elucidation of complex natural products. View this paper
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Articles (326)

  • Article
  • Open Access
1 Citations
1,599 Views
17 Pages

Biofunctionalization of Magneto-Plasmonic Fe3O4@SiO2-NH2-Au Heterostructures with the Cellulase from Trichoderma reesei

  • Anna Tomaszewska,
  • Magdalena Kulpa-Greszta,
  • Oliwia Hryców,
  • Klaudia Niemczyk,
  • Renata Wojnarowska-Nowak,
  • Daniel Broda and
  • Robert Pazik

6 February 2025

The study focuses on the synthesis of Fe3O4@SiO2-NH2-Au heterostructures with magneto-plasmonic properties composed of well-defined cubic Fe3O4 cores (79 nm) covered with 10 nm silica shell and gold nanoparticles (8 nm) fabricated on silica shell. Th...

  • Review
  • Open Access
4 Citations
2,044 Views
30 Pages

Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years

  • Francesca Mancuso,
  • Carla Di Chio,
  • Francesca Di Matteo,
  • Gerardina Smaldone,
  • Nunzio Iraci and
  • Salvatore Vincenzo Giofrè

6 February 2025

The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex. Bey...

  • Article
  • Open Access
4 Citations
2,335 Views
13 Pages

6 February 2025

Peptides isolated from various biological materials are potential sources for novel angiotensin-converting enzyme (ACE) inhibitors. Here, the ACE-inhibitory activity of peptides derived from papain-digested hydrolysates of porcine liver and placenta...

  • Article
  • Open Access
2 Citations
2,939 Views
11 Pages

Spray-Drying Synthesis of Na4Fe3(PO4)2P2O7@CNT Cathode for Ultra-Stable and High-Rate Sodium-Ion Batteries

  • Jinri Huang,
  • Ziheng Zhang,
  • Daiqian Chen,
  • Hesheng Yu,
  • Yu Wu and
  • Yuanfu Chen

6 February 2025

Iron-based phosphate is a promising cathode for sodium-ion batteries due to its low cost and abundant resources; however, the practical application is hindered by poor electronic conductivity, sluggish Na+ diffusion, and a lack of low-cost and scalab...

  • Article
  • Open Access
1 Citations
1,181 Views
17 Pages

Zephycandidine A and Synthetic Analogues—Synthesis and Evaluation of Biological Activity

  • Thomas Klaßmüller,
  • Florian Lengauer,
  • Julia Blenninger,
  • Franz Geisslinger,
  • Karin Bartel and
  • Franz Bracher

6 February 2025

A convenient total synthesis of the imidazo[1,2-f]phenanthridine-type Amaryllidaceae alkaloid zephycandidine A (3) was developed, which further allowed us to perform modifications of substituents on benzenoid ring A and imidazole ring D. The biologic...

  • Article
  • Open Access
2 Citations
1,112 Views
12 Pages

Voltammetric Determination of the Total Content of the Most Commonly Occurring Estrogens in Water Media

  • Jaromíra Chýlková,
  • Jan Bartáček,
  • Natálie Měchová,
  • Miloš Sedlák and
  • Jiří Váňa

6 February 2025

Estrogens in aquatic environments pose significant ecological and health risks due to their cumulative effects rather than individual impacts. This study investigates the voltammetric behavior of estrone (E1), 17β-estradiol (E2), estriol (E3), a...

  • Article
  • Open Access
1,184 Views
14 Pages

Synthesis and Anti-Inflammatory Evaluation of Novel Hybrids of 7-Oxodehydroabietic Acid Bearing a 1,2,3-Triazole Moiety

  • Wen-Tao Fang,
  • Yong-Feng Lv,
  • Fu-Cai Ren,
  • Hong Zhang,
  • Dong-Mei Xie,
  • Xiao-Bo Zhang,
  • Cheng-Wu Fang,
  • Shou-Jin Liu and
  • Han Luo

6 February 2025

To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of 1H NMR, 13C NMR, and ESI-HRMS....

  • Article
  • Open Access
7 Citations
1,447 Views
14 Pages

6 February 2025

Homogeneous aptasensors that eliminate the need for probe labeling or immobilization hold significant potential for the rapid detection of tumor biomarkers. Herein, a homogeneous aptasensor with electrochemical (EC) and electrochemiluminescence (ECL)...

  • Article
  • Open Access
1 Citations
2,842 Views
21 Pages

Bioactive Potential and Chemical Composition of Vitex agnus-castus L. Leaf Extracts Collected in Algeria: A Combined In Vitro and In Silico Approach

  • Amina Bramki,
  • Ghozlane Barboucha,
  • Ouided Benslama,
  • Anna Andolfi,
  • Fatima Zohra Makhlouf,
  • Maria Smati,
  • Djamila Benouchenne,
  • Mohamed Moussaoui,
  • Chawki Bensouici and
  • Alessio Cimmino
  • + 3 authors

6 February 2025

Vitex agnus-castus L., a medicinal plant widespread in the Middle East and Europe, is traditionally used to treat various disorders. In this study, extracts from its leaves, collected in Algeria, were evaluated for their antioxidant, enzymatic, and a...

  • Review
  • Open Access
24 Citations
28,315 Views
32 Pages

Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential

  • Adina Alberts,
  • Elena-Theodora Moldoveanu,
  • Adelina-Gabriela Niculescu and
  • Alexandru Mihai Grumezescu

6 February 2025

Since Albert Szent-Györgyi discovered it and it became used in treating scurvy, vitamin C has attracted interest in many studies due to its unique properties. It is an important cofactor in the synthesis of collagen and hormones, and it is invol...

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Molecules - ISSN 1420-3049Creative Common CC BY license