Molecules, Volume 30, Issue 3

The study focuses on the synthesis of Fe₃O₄@SiO₂-NH₂-Au heterostructures with magneto-plasmonic properties composed of well-defined cubic Fe₃O₄ cores (79 nm) covered with 10 nm silica shell and gold nanoparticles (8 nm) fabricated on silica shell. Th...

The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex. Bey...

Peptides isolated from various biological materials are potential sources for novel angiotensin-converting enzyme (ACE) inhibitors. Here, the ACE-inhibitory activity of peptides derived from papain-digested hydrolysates of porcine liver and placenta...

Iron-based phosphate is a promising cathode for sodium-ion batteries due to its low cost and abundant resources; however, the practical application is hindered by poor electronic conductivity, sluggish Na⁺ diffusion, and a lack of low-cost and scalab...

A convenient total synthesis of the imidazo[1,2-f]phenanthridine-type Amaryllidaceae alkaloid zephycandidine A (3) was developed, which further allowed us to perform modifications of substituents on benzenoid ring A and imidazole ring D. The biologic...

Estrogens in aquatic environments pose significant ecological and health risks due to their cumulative effects rather than individual impacts. This study investigates the voltammetric behavior of estrone (E1), 17β-estradiol (E2), estriol (E3), a...

To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of ¹H NMR, ¹³C NMR, and ESI-HRMS....

Homogeneous aptasensors that eliminate the need for probe labeling or immobilization hold significant potential for the rapid detection of tumor biomarkers. Herein, a homogeneous aptasensor with electrochemical (EC) and electrochemiluminescence (ECL)...

Vitex agnus-castus L., a medicinal plant widespread in the Middle East and Europe, is traditionally used to treat various disorders. In this study, extracts from its leaves, collected in Algeria, were evaluated for their antioxidant, enzymatic, and a...

Since Albert Szent-Györgyi discovered it and it became used in treating scurvy, vitamin C has attracted interest in many studies due to its unique properties. It is an important cofactor in the synthesis of collagen and hormones, and it is invol...

N,N-dimethylformamide’s (DMF) participation in domino reactions has been developed. Starting from substituted halogenobenzenes and selenium powder, versatile biologically active Se-phenyl dimethylcarbamoselenoate derivatives were efficiently sy...

A novel Schiff base, (E)-4-acetyl-N-(4-hydroxy-3-methoxybenzylidene)aniline (abbreviated as ANHMA), was synthesized and characterized using infrared and ¹H- and ¹³C-NMR spectroscopies. Optical properties in different solvents were evaluated using UV-...

A visible-light-mediated strategy for the direct oxygenation of N-substituted tetrahydroisoquinolines and isoindolines to the corresponding benzo-fused lactams under clean conditions without using any external photocatalysts has been developed. The r...

Absorption of exudates is crucial for moist wound treatment, particularly in chronic wound care applications. However, controlling wound exudates with current gel-based wound dressings has challenges, such as the risk of bacterial infection during lo...

Peptides are an important class of biomolecules that perform many physiological functions and which occupy a significant and increasing share of the pharmaceutical market. Methods to determine the solid-state structures of peptides in different envir...

The modification of catalytic activity through the use of metallic promoters is a key strategy for optimizing performance, as electronic factors play a crucial role in regulating catalytic behavior. This study explores the electronic factors behind t...

The Gibbs free energies of gallic acid (GA) and its anionic forms in aqueous solution were computed utilizing density functional theory (DFT) at the LSDA, M062X, B3LYP/QZVP levels, in conjunction with the SMD solvation model. The pK_a values correspon...

Objective: A pentacyclic triterpene, oleanolic acid (OA), has anti-inflammatory activity. The role of oleanolic acid in aging is poorly understood, and the regulatory mechanism of IGF-1 signaling in aging is still not fully understood. Thus, we hypot...

Two-dimensional materials have become a cornerstone of modern materials science, offering unique structural, electronic, optical, and mechanical properties [...]

Fullerenes, a unique allotrope of carbon, have captured significant attention in multiple scientific fields. As a non-destructive characterization technique, Raman spectroscopy has proven indispensable for investigating fullerenes and their derivativ...

This study investigates heterocyclic gamma-butyrobetaine (GBB) analogs as metabolic modulators through an integrated approach involving rational design, molecular docking, synthesis, and in vitro evaluation. The compounds synthesized demonstrated pro...

Eriobotrya japonica (Thunb.) Lindl., commonly known as loquat, is a plant belonging to the Rosaceae family. While its fruit is widely consumed as food and used in traditional medicine, research on other parts of the plant remains insufficient. Theref...

Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy. Fluorescent probes for this approach can be constructed by linking an a...

Arnebia euchroma (Royle) Johnst. has high medicinal and economic value, but in recent years, wild resources of this species have been depleted and the quality of artificially cultivated A. euchroma has been poor. The endophyte community of medicinal...

Pressure-induced nitrogen-rich compounds hold significant application prospects in high-energy-density materials. Utilizing first-principles calculations and swarm-intelligence structure search methods, we have identified ten new types of Gd-N compou...

The design, construction, and operation of devices and machines at the molecular scale using the bottom-up approach captivates a lot of interest in nanoscience. Particularly intriguing are interlocked molecular architectures, which are ideal candidat...

Biomaterials represent a distinct class of materials used in various medical applications, such as replicating the shape or function of damaged tissue caused by disease or trauma. The increasing focus on polyhydroxyalkanoate (PHA) research can be att...

Bismuth-based materials that adhere to the alloy/dealloy reaction mechanism are regarded as highly promising anode materials for potassium-ion batteries due to their high volume-specific capacity and moderate reaction potentials. However, their comme...

Pyrolysis technology, as a method for recycling waste polystyrenes (WPs), is widely regarded as an effective means to achieve the high value reutilization of WPs due to its environmental friendliness and the renewability of the resources used. Howeve...

Sebum lipids, accessible via groomed latent fingerprints, may be a valuable, underappreciated sample source for future biomarker research. Sampling sebum lipids from the skin is painless for patients, efficient for researchers, and has already demons...

Recent studies have shown that DHA supplementation in the form of phospholipids effectively increases DHA levels in the brain, including DHA lysophospholipids. This research explores a method to produce DHA lysophosphatidylcholine (DHA-LPC) using lip...

The genus Seseli L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, Seseli foliosum (Somm. et Levier) Manden., is notable for its unique pharmacological properties. To our knowledge, compre...

This study presents a tentative synthesis of supported H-shaped and ladder-type compounds. If the ladders were not accessible, probably due to distance misfits between the reactive centers, a facile method for the synthesis of H-shaped N-alkylated am...

Polygonatum cyrtonema Hua (PCH) belongs to the genus Polygonatum Mill of the Liliaceae family. As a traditional tonic herb, the rhizome of PCH has been widely used as a functional food and traditional Chinese medicine, mainly for the treatment of spl...

There has been no chemical analysis of the fruit of medicinal plant Jatropha podagrica until now. The current study aimed to qualitatively and quantitatively analyze the J. podagrica fruit using a high-resolution LC-MS strategy, i.e., library-compari...

Due to its central role in pain, inflammation, and related disorders, the Transient Receptor Potential (TPR) Vanilloid Type-1 (TRPV1) ion channel represents an attractive target for the development of novel antinociceptive and anti-inflammatory agent...

The aroma composition of condensed hardwood smoke generated from a mixed hardwood was characterized by gas chromatography–mass spectrometry/olfactometry analysis. Twenty-seven odorants with a flavor dilution value ≥4 were identified and quan...

Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors. C...

The organic light-emitting diode (OLED) has been regarded as the most prominent product in the current market of organic electronics, which has attracted growing attention because of their applications in full-color displays and solid-state lighting....

Wood serves as a green biomass material with sustainable utilization and environmental friendliness. The modification of wood can be used to obtain superhydrophobic properties and further expand wood’s application range. This paper focuses on t...

Cannabinoid molecules are the family of molecules that bind to the cannabinoid receptors (CB1 and CB2) of the human body and cause changes in numerous biological functions including motor coordination, emotion, and pain reception. Cannabinoids occur...

This study investigates the extraction, characterization, and cosmetic application of silk sericin, a protein derived from Bombyx mori silkworm cocoons, with a focus on its potential in sustainable and biodegradable cosmetic formulations. Sericin was...

The chemical complexity of natural products, such as Eugenia punicifolia (Kunth) DC. plant, presents a challenge when extracting and identifying bioactive compounds. This study investigates the impact of different extraction systems and seasonal vari...

The formation of the siloxane bond is one of the most important reactions used in silicone chemistry and technology. In this paper, a new process for the condensation of alkoxy-functional silanes to form a siloxane bond is presented. The new reaction...

Understanding characteristic post-source decay (PSD) fragmentation patterns in tandem mass spectrometry (MS/MS) is important for the identification of target molecules. In this study, we explored the characteristic PSD patterns associated with O-link...

This study investigated Rhodamine B (RhB) degradation by electro-Fenton (EF), anodic oxidation (AO), and their combination (EF/AO), using a carbon felt cathode coupled to a sub-stoichiometric titanium dioxide Magnéli phase (Ti₄O₇) anode or a p...

Now under Clusiaceae and Hypericaceae, Clusia and Hypericum were previously categorized under one family until they were divided in 2003 by the APG III system. The Clusia genus is characterized by the presence of tocotrienol derivatives with antiangi...

This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and Pi...

Polydentate ligands with nitrogen donor atoms have possibly given rise to the largest group of coordination complexes described. Among these ligands, amidinates represent a nitrogenated version of carboxylates and allow the formation of complexes wit...

Two-dimensional tin halide perovskites are of significant interest for light emitting applications. Here, we investigate the effect of organic cation A on the stability of different Dion–Jacobson tin-based halide perovskites. The ASnBr₄ materia...