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Molecules, Volume 30, Issue 10

May-2 2025 - 167 articles

Cover Story: The heptameric Panx1 channel, despite its recent discovery and characterization, has been found to be involved in a variety of diseases, such as neuropathic pain, ischemic stroke, and cancer. It was recently found to be abundantly expressed in the renal collecting ducts in autosomal dominant polycystic kidney disease (ADPKD). Thus, research addressing the discovery of new Panx1 channel blockers is very helpful. We report here the design and synthesis of quinolone derivatives and Mefloquine-based compounds as new Panx1 blockers. The more potent compound was able to slow renal cyst formation as well as reduce the dimensions of the cysts in a mouse model of APDKD. This molecular modelling study provides evidence of the interaction between the most active ligand and the amino acids of the channel. View this paper
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Articles (167)

  • Article
  • Open Access
892 Views
12 Pages

Identification of the Cytotoxic Transglutaminase from Mycobacterium spp. That Is Involved in RIPK1 Activation

  • Xinting Zhang,
  • Yikai Zhang,
  • Xiao Feng,
  • Yueying Wang,
  • Si-Shang Li,
  • Mei-Yi Yan,
  • Yi-Cheng Sun,
  • Qi Jin and
  • Feng Jiang

Although the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The Mycobacterium tuberculosis complex (MTBC) including M. tuberculosis, M. bovis, M. microti, etc., is the deadl...

  • Article
  • Open Access
807 Views
20 Pages

Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method

  • Saule B. Zhautikova,
  • Nursipat N. Abdykhanova,
  • Dmitry A. Fedorishin,
  • Yelena G. Shapovalova,
  • Andrei I. Khlebnikov,
  • Abdigali A. Bakibaev,
  • Irina A. Kurzina,
  • Saule K. Kabieva,
  • Nazerke Boranbay and
  • Gaziza M. Zhumanazarova

In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level...

  • Review
  • Open Access
3 Citations
1,404 Views
19 Pages

Natural Compounds and Health Benefits of Ganoderma capense

  • Longshi Liu,
  • Xinge Shi,
  • Longkang Jia,
  • Ran Wang and
  • Chengwei Liu

Ganoderma capense, a member of the Ganoderma genus within the Polyporaceae family, has long been recognized for its high nutritional value and extensive use in traditional medicine. Its primary distribution is in China and South Africa, with the type...

  • Review
  • Open Access
3,740 Views
134 Pages

Oxygen reduction reaction (ORR) is one of the most important reactions in electrochemical energy storage and conversion devices. To overcome the slow kinetics, minimize the overpotential, and make this reaction feasible, efficient, and stable, electr...

  • Article
  • Open Access
931 Views
13 Pages

Probes sensitive to mechanical stress are in high demand for analyzing pressure distributions in materials. Metal–organic frameworks (MOFs) are especially promising for designing pressure sensors due to their structural tunability. In this work...

  • Article
  • Open Access
1,924 Views
14 Pages

A Natural Inhibitor, 1′S-1′-Acetoxychavicol Acetate, Against Testosterone-Induced Alopecia via NADPH Oxidase Regulation

  • Kkotnara Park,
  • Isoo Youn,
  • Jung Min Suh,
  • Min Hye Choi,
  • Da-Woon Bae,
  • Soo-Bong Park,
  • Mi Hee Kwack,
  • Sun-Shin Cha,
  • Dae Sik Jang and
  • Young Kwan Sung
  • + 2 authors

Androgenetic alopecia is associated with testosterone-mediated anagen-to-catagen transition and matrix keratinocyte apoptosis in hair follicle cells. Activation of Nox isozymes is involved in testosterone-mediated keratinocyte apoptosis, leading to a...

  • Review
  • Open Access
7 Citations
6,037 Views
34 Pages

Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity

  • Zarifa Murtazaeva,
  • Azizbek Nasrullaev,
  • Anvarjon Buronov,
  • Shukhrat Gaybullaev,
  • Lifei Nie,
  • Sodik Numonov,
  • Zohidjon Khushnazarov,
  • Davron Turgunov,
  • Rustamkhon Kuryazov and
  • Jiangyu Zhao
  • + 1 author

Imidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of the ring. The imidazole scaffold is particularly suited for kinase inhibition concepts. This further confirms that this scaffold is a pri...

  • Article
  • Open Access
3 Citations
1,202 Views
20 Pages

A complex salt roasting–water leaching process was developed and optimized for the efficient extraction of lithium (Li), rubidium (Rb), and cesium (Cs) from lepidolite. The effects of roasting parameters (temperature, time, and complex salt com...

  • Review
  • Open Access
3,205 Views
22 Pages

Coherent Vibrational Anti-Stokes Raman Spectroscopy Assisted by Pulse Shaping

  • Kai Wang,
  • James T. Florence,
  • Xia Hua,
  • Zehua Han,
  • Yujie Shen,
  • Jizhou Wang,
  • Xi Wang and
  • Alexei V. Sokolov

Coherent anti-Stokes Raman scattering (CARS) is a powerful nonlinear spectroscopic technique widely used in biological imaging, chemical analysis, and combustion and flame diagnostics. The adoption of pulse shapers in CARS has emerged as a useful app...

  • Article
  • Open Access
1 Citations
1,183 Views
16 Pages

The valence bond (VB) framework is widely recognized as a powerful tool for elucidating the electronic origins of activation energy barriers in chemical reactions. We employed ab initio VB calculations to investigate the hydrogen abstraction (H-abstr...

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Molecules - ISSN 1420-3049