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Molecules, Volume 29, Issue 23

December-1 2024 - 329 articles

Cover Story: Scorpionates, tridentate ligands known for their versatile coordination properties, have emerged as promising scaffolds in cancer therapy. This review explores their unique potential, focusing on metal-based complexes like copper and ruthenium, which exhibit cytotoxic activity by disrupting mitochondrial function and generating reactive oxygen species. Ligand modifications, such as sulfur heterocycles and unsubstituted pyrazoles, enhance stability and selectivity. Despite significant findings on these ligands, scorpionates remain underexplored in systematic structure–activity studies. Their diverse chemistry and selective biological mechanisms hold potential for next-generation anticancer therapeutics. View this paper
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Articles (329)

  • Article
  • Open Access
1 Citations
1,221 Views
12 Pages

Theoretical Prediction of Divalent Actinide Borozene Complexes

  • Naixin Zhang,
  • Qunyan Wu,
  • Jianhui Lan,
  • Weiqun Shi and
  • Congzhi Wang

9 December 2024

The aromatic boron cluster B82– (D7h) has similar π bonding to C6H6, which is named “borozene”. The B82– ligand has been observed to stabilize monovalent Ln(+I) in C7v-LnB8− (Ln = La, Pr, Tb, Tm, and Yb) borozene comp...

  • Article
  • Open Access
2 Citations
1,271 Views
18 Pages

Non-Contact Interaction Between Phorbol Myristate Acetate and Aqueous Alcohol Solutions Under Combined Magnetic Fields

  • Vadim V. Novikov,
  • Elena V. Yablokova,
  • German O. Stepanov,
  • Natalia N. Rodionova,
  • Sergey A. Tarasov,
  • Ekaterina V. Buravleva,
  • Olga I. Yablonskaya and
  • Vladimir L. Voeikov

9 December 2024

Previous research has demonstrated that a combined magnetic field (CMF) plays a critical role in modifying the properties of aqueous solutions, leading to an increase in the luminol-enhanced chemiluminescence of neutrophils. Using this model, the dis...

  • Article
  • Open Access
1 Citations
1,325 Views
16 Pages

Enrichment of Ginseng Rare Sapogenin 25-OH-PPT and Its Protective Effect on Myocardial Fibrosis

  • Zixuan Jin,
  • Yuemin Wu,
  • Yanyan Zhang,
  • Siqi Feng,
  • Guotao Hu,
  • Hairong Liu,
  • Yuqing Zhao and
  • Jing Xu

9 December 2024

Ginseng (Panax ginseng C. A. Meyer), a traditional Chinese medicine, and the rare ginsenosides contained in it have various physiological activities. 25-OH-PPT (T19) is a rare natural dammarane-type ginseng sapogenin. Pharmacological studies have sho...

  • Article
  • Open Access
1,874 Views
11 Pages

9 December 2024

The hypervalent iodine-mediated formation of steroidal 5/5-spiroiminals and 5/5-spiroaminals from steroidal amines is presented. Under the influence of excess PhI(OAc)2 and iodine in acetonitrile at 0 °C, steroidal amines smoothly underwent cycli...

  • Article
  • Open Access
2 Citations
1,758 Views
25 Pages

9 December 2024

Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is a key regulator of biological processes. Owing to the inherent structural complexity of HS, structure-to-function studies with its ligan...

  • Article
  • Open Access
2 Citations
1,674 Views
17 Pages

9 December 2024

Cyanostilbene (CS)-related conjugated groups can be considered as dual functional groups of AIEgen and mesogen to construct photoluminescent liquid crystals, and it is essential to study the relationship between their molecular structures and compoun...

  • Article
  • Open Access
4 Citations
1,259 Views
13 Pages

9 December 2024

The concept of superhalogen was proposed for more than 40 years, and it has never been associated with planar tetracoordinate fluorine (ptF) species. In this work, using Li as the ligands and Cl, Br, I as the auxiliary atoms, we have designed the sta...

  • Review
  • Open Access
6 Citations
4,422 Views
17 Pages

Current Role and Potential of Triple Quadrupole Mass Spectrometry in Biomedical Research and Clinical Applications

  • Andreas Tsakalof,
  • Alexey A. Sysoev,
  • Kira V. Vyatkina,
  • Alexander A. Eganov,
  • Nikolay N. Eroshchenko,
  • Alexey N. Kiryushin,
  • Alexey Yu. Adamov,
  • Elena Yu. Danilova and
  • Alexander E. Nosyrev

9 December 2024

Mass-spectrometry-based assays nowadays play an essential role in biomedical research and clinical applications. There are different types of commercial mass spectrometers on the market today, and triple quadrupole (QqQ) is one of the time-honored sy...

  • Article
  • Open Access
1,302 Views
24 Pages

9 December 2024

Triarylamine groups have been widely utilized in the development of high-performance charge-transporting or luminescent materials for fabricating organic light-emitting diodes (OLEDs). In this study, atmospheric pressure chemical ionization (APCI) Q-...

  • Review
  • Open Access
7 Citations
3,641 Views
20 Pages

9 December 2024

Cinnamic acid and its natural derivatives were primarily used in cosmetics as fragrance materials as well as skin and hair conditioners. Nowadays, not only natural but also synthetic cinnamic acid derivatives are used as active ingredients of cosmeti...

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Molecules - ISSN 1420-3049