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Molecules, Volume 27, Issue 6

March-2 2022 - 284 articles

Cover Story: Vitamins D are a group of fat-soluble secosteroids which play a regulatory role in the functioning of most cells. Rational design of new vitamin D analogs of increased therapeutic potency and lowered calcemic side effects requires high-resolution initial structures and a deep understanding of interactions with the vitamin D receptor. In this paper, using quantum crystallography methods, we present the first determination of the experimental quantitative charge density of an advanced intermediate of vitamin D analogues as well as a reconstruction of the theoretical electron density of final vitamin D analogues. Application of these methods allows for topological and electrostatic interaction energy analysis which is  important for understanding biological effects. View this paper
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Articles (284)

  • Article
  • Open Access
20 Citations
4,436 Views
12 Pages

21 March 2022

A nanofiber metal–organic framework filter, a polyacrylonitrile (PAN) nanofiber membrane composite with an iron/2-amino-terephthalic acid-based metal–organic framework (MIL101(Fe)-NH2), was prepared by one-step electrospinning. MIL101(Fe)...

  • Article
  • Open Access
10 Citations
3,949 Views
14 Pages

Automated Synthesis of 68Ga-Labeled DOTA-MGS8 and Preclinical Characterization of Cholecystokinin-2 Receptor Targeting

  • Anton Amadeus Hörmann,
  • Elisabeth Plhak,
  • Maximilian Klingler,
  • Christine Rangger,
  • Joachim Pfister,
  • Gert Schwach,
  • Herbert Kvaternik and
  • Elisabeth von Guggenberg

21 March 2022

The new minigastrin analog DOTA-MGS8 targeting the cholecystokinin-2 receptor (CCK2R) used in this study displays the combination of two site-specific modifications within the C-terminal receptor binding sequence together with an additional N-termina...

  • Article
  • Open Access
7 Citations
3,744 Views
14 Pages

21 March 2022

In this work, new electrochemical sensors based on the modification of glassy carbon electrode (GCE) with multiwalled carbon nanotubes (MWCNTs)—rare metal oxides (REMO) nanocomposites were fabricated by drop-to-drop method of MWCNTs-REMO disper...

  • Article
  • Open Access
14 Citations
4,732 Views
12 Pages

21 March 2022

Antibacterial substances such as sulfonamides are widely used in veterinary medicine to treat many bacterial diseases. After their administration to animals, up to 90% of the initial dose of the antibiotic is excreted in the feces and/or urine, which...

  • Review
  • Open Access
34 Citations
7,204 Views
26 Pages

Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy

  • Nur Hanisah Mustafa,
  • Mahendran Sekar,
  • Shivkanya Fuloria,
  • M. Yasmin Begum,
  • Siew Hua Gan,
  • Nur Najihah Izzati Mat Rani,
  • Subban Ravi,
  • Kumarappan Chidambaram,
  • Vetriselvan Subramaniyan and
  • Kathiresan V. Sathasivam
  • + 6 authors

21 March 2022

Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemarrhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological...

  • Article
  • Open Access
2 Citations
3,138 Views
16 Pages

21 March 2022

Autolysis is a common physiological process in eukaryotic cells that is often prevented or applied, especially in yeast expression systems. In this study, an antimicrobial peptide from chicken (AMP) was recombinantly expressed in the Pichia pastoris...

  • Review
  • Open Access
7 Citations
6,181 Views
47 Pages

Preparation and Synthetic Applications of Five-to-Seven-Membered Cyclic α-Diazo Monocarbonyl Compounds

  • Daniil Zhukovsky,
  • Dmitry Dar’in,
  • Olga Bakulina and
  • Mikhail Krasavin

21 March 2022

The reactivity of cyclic α-diazo monocarbonyl compounds differs from that of their acyclic counterparts. In this review, we summarize the current literature available on the synthesis and synthetic applications of three major classes of cyclic...

  • Article
  • Open Access
10 Citations
3,136 Views
14 Pages

Reduction in Allergenicity and Induction of Oral Tolerance of Glycated Tropomyosin from Crab

  • Xin-Yu Han,
  • Tian-Liang Bai,
  • Huang Yang,
  • Yi-Chen Lin,
  • Nai-Ru Ji,
  • Yan-Bo Wang,
  • Ling-Lin Fu,
  • Min-Jie Cao,
  • Jing-Wen Liu and
  • Guang-Ming Liu

21 March 2022

Tropomyosin (TM) is an important crustacean (Scylla paramamosain) allergen. This study aimed to assess Maillard-reacted TM (TM-G) induction of allergenic responses with cell and mouse models. We analyzed the difference of sensitization and the abilit...

  • Article
  • Open Access
8 Citations
2,795 Views
14 Pages

Effect of High Hydrostatic Pressure in the Storage of Spanish-Style Table Olive Fermented with Olive Leaf Extract and Saccharomyces cerevisiae

  • Daniel Martín-Vertedor,
  • Thais Schaide,
  • Emanuele Boselli,
  • Manuel Martínez,
  • Jesús García-Parra and
  • Francisco Pérez-Nevado

21 March 2022

Olives treated according to the Spanish-style are firstly treated with caustic soda and then fermented in brine to reduce phenols. Next, olives are packed and subjected to pasteurization. The effect of different high hydrostatic pressure treatments (...

  • Article
  • Open Access
53 Citations
5,829 Views
16 Pages

Ultrastable Conjugated Microporous Polymers Containing Benzobisthiadiazole and Pyrene Building Blocks for Energy Storage Applications

  • Mohamed Gamal Mohamed,
  • Tharwat Hassan Mansoure,
  • Maha Mohamed Samy,
  • Yasuno Takashi,
  • Ahmed A. K. Mohammed,
  • Tansir Ahamad,
  • Saad M. Alshehri,
  • Jeonghun Kim,
  • Babasaheb M. Matsagar and
  • Kevin C.-W. Wu
  • + 1 author

21 March 2022

In recent years, conjugated microporous polymers (CMPs) have become important precursors for environmental and energy applications, compared with inorganic electrode materials, due to their ease of preparation, facile charge storage process, π-con...

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Molecules - ISSN 1420-3049