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Review

Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma

by
Narayan D. Chaurasiya
1,*,
Francisco Leon
2,*,
Ilias Muhammad
3,* and
Babu L. Tekwani
1,*
1
Scientific Platforms, Southern Research, Birmingham, AL 35205, USA
2
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
3
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
*
Authors to whom correspondence should be addressed.
Molecules 2022, 27(13), 4297; https://doi.org/10.3390/molecules27134297
Submission received: 30 April 2022 / Revised: 29 June 2022 / Accepted: 29 June 2022 / Published: 4 July 2022
(This article belongs to the Special Issue Exclusive Feature Papers in Natural Products Chemistry)
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Abstract

Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs. This review presents a comprehensive survey of the natural products, predominantly from plant sources, as potential new MAOI drug leads. The psychoactive properties of several traditionally used plants and herbal formulations were attributed to their MAOI constituents. MAO inhibitory constituents may also be responsible for neuroprotective effects of natural products. Different classes of MAOIs were identified from the natural product sources with non-selective as well as selective inhibition of MAO-A and -B. Selective reversible natural product MAOIs may be safer alternatives to the conventional MAOI drugs. Characterization of MAO inhibitory constituents of natural products traditionally used as psychoactive preparations or for treatment of neurological disorders may help in understanding the mechanism of action, optimization of these preparations for desired bioactive properties, and improvement of the therapeutic potential. Potential therapeutic application of natural product MAOIs for treatment of neuroblastoma is also discussed.
Keywords: natural products; monoamine oxidases (MAO-A and -B); antidepressant; monoamine oxidase inhibitors; neurological disorders; neuroprotection; Parkinson’s disease; neuroblastoma natural products; monoamine oxidases (MAO-A and -B); antidepressant; monoamine oxidase inhibitors; neurological disorders; neuroprotection; Parkinson’s disease; neuroblastoma

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MDPI and ACS Style

Chaurasiya, N.D.; Leon, F.; Muhammad, I.; Tekwani, B.L. Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma. Molecules 2022, 27, 4297. https://doi.org/10.3390/molecules27134297

AMA Style

Chaurasiya ND, Leon F, Muhammad I, Tekwani BL. Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma. Molecules. 2022; 27(13):4297. https://doi.org/10.3390/molecules27134297

Chicago/Turabian Style

Chaurasiya, Narayan D., Francisco Leon, Ilias Muhammad, and Babu L. Tekwani. 2022. "Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma" Molecules 27, no. 13: 4297. https://doi.org/10.3390/molecules27134297

APA Style

Chaurasiya, N. D., Leon, F., Muhammad, I., & Tekwani, B. L. (2022). Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma. Molecules, 27(13), 4297. https://doi.org/10.3390/molecules27134297

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