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Open AccessArticle

Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Bulaksumur, Yogyakarta 55281, Indonesia
Chemistry Education Department, Kampus III Paingan, Universitas Sanata Dharma, Yogyakarta 55281, Indonesia
Department of Chemistry, Sogang University, Seoul 04107, Korea
Author to whom correspondence should be addressed.
Academic Editors: David Díez and María Ángeles Castro
Molecules 2021, 26(9), 2698;
Received: 8 April 2021 / Revised: 29 April 2021 / Accepted: 30 April 2021 / Published: 4 May 2021
(This article belongs to the Special Issue Application of Organic Synthesis to Bioactive Compounds II)
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region. Therefore, in the present work, we synthesized eight chalcone derivatives through Claisen–Schmidt condensation at room temperature. The evaluation of the optical properties of each chalcone derivatives in the UV region was conducted through spectroscopic and computational studies. The synthesized chalcones were obtained in good yields and they were active in the UV region. The results revealed that more methoxy substituents to chalcone leads toward red shift. All chalcone derivatives have high molar absorptivity value (21,000–56,000) demonstrating that they have the potential to be used as the sunscreen agent. The cytotoxicity assay showed that chalcone derivatives were demonstrating low toxicity toward normal human fibroblast cell, which is remarkable. Therefore, we concluded that the synthesized chalcones in this work were potential to be developed as novel sunscreen agents in real application. View Full-Text
Keywords: chalcone; synthesis; UV-activity; cytotoxicity; sunscreen chalcone; synthesis; UV-activity; cytotoxicity; sunscreen
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MDPI and ACS Style

Wijayanti, L.W.; Swasono, R.T.; Lee, W.; Jumina, J. Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent. Molecules 2021, 26, 2698.

AMA Style

Wijayanti LW, Swasono RT, Lee W, Jumina J. Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent. Molecules. 2021; 26(9):2698.

Chicago/Turabian Style

Wijayanti, Lucia W.; Swasono, Respati T.; Lee, Wonkoo; Jumina, Jumina. 2021. "Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent" Molecules 26, no. 9: 2698.

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