Next Article in Journal
Catechol-Based Antimicrobial Polymers
Previous Article in Journal
Bicyclic Basic Merbarone Analogues as Antiproliferative Agents
Previous Article in Special Issue
A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids
Open AccessReview

The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications

1
Dipartimento di Scienza del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy
2
Dipartimento di Farmacia, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: Michail N. Elinson and Erika Bálint
Molecules 2021, 26(3), 558; https://doi.org/10.3390/molecules26030558
Received: 17 November 2020 / Revised: 14 January 2021 / Accepted: 16 January 2021 / Published: 21 January 2021
Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929–1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it. View Full-Text
Keywords: Bargellini reaction; multicomponent reaction; chloroform; chlorobutanol; α-aryl isobutyric acids Bargellini reaction; multicomponent reaction; chloroform; chlorobutanol; α-aryl isobutyric acids
Show Figures

Figure 1

MDPI and ACS Style

Serafini, M.; Murgia, I.; Giustiniano, M.; Pirali, T.; Tron, G.C. The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications. Molecules 2021, 26, 558. https://doi.org/10.3390/molecules26030558

AMA Style

Serafini M, Murgia I, Giustiniano M, Pirali T, Tron GC. The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications. Molecules. 2021; 26(3):558. https://doi.org/10.3390/molecules26030558

Chicago/Turabian Style

Serafini, Marta; Murgia, Ilaria; Giustiniano, Mariateresa; Pirali, Tracey; Tron, Gian C. 2021. "The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications" Molecules 26, no. 3: 558. https://doi.org/10.3390/molecules26030558

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop