The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications
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Dipartimento di Scienza del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy
2
Dipartimento di Farmacia, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: Michail N. Elinson and Erika Bálint
Molecules 2021, 26(3), 558; https://doi.org/10.3390/molecules26030558
Received: 17 November 2020
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Revised: 14 January 2021
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Accepted: 16 January 2021
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Published: 21 January 2021
(This article belongs to the Special Issue Old and New Multicomponent Reactions and Their Applications in Different Fields)
Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929–1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it.
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Keywords:
Bargellini reaction; multicomponent reaction; chloroform; chlorobutanol; α-aryl isobutyric acids
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MDPI and ACS Style
Serafini, M.; Murgia, I.; Giustiniano, M.; Pirali, T.; Tron, G.C. The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications. Molecules 2021, 26, 558. https://doi.org/10.3390/molecules26030558
AMA Style
Serafini M, Murgia I, Giustiniano M, Pirali T, Tron GC. The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications. Molecules. 2021; 26(3):558. https://doi.org/10.3390/molecules26030558
Chicago/Turabian StyleSerafini, Marta, Ilaria Murgia, Mariateresa Giustiniano, Tracey Pirali, and Gian Cesare Tron. 2021. "The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications" Molecules 26, no. 3: 558. https://doi.org/10.3390/molecules26030558
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