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Structural Elucidation of Malonylcommunol and 6β-Hydroxy-trans-communic Acid, Two Undescribed Diterpenes from Salvia cinnabarina. First Examples of Labdane Diterpenoids from a Mexican Salvia Species

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City 04510, Mexico
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Molecules 2020, 25(8), 1808; https://doi.org/10.3390/molecules25081808
Received: 29 February 2020 / Revised: 5 April 2020 / Accepted: 8 April 2020 / Published: 15 April 2020
(This article belongs to the Section Natural Products Chemistry)
The aerial parts of Salvia cinnabarina afforded two undescribed labdane diterpenoids 1 and 2 (malonylcommunol and 6β-hydroxy-trans-communic acid) along with two known labdane diterpenoids, trans-communic acid (3) and trans-communol (4). Additionally, seven known metabolites were also isolated; two isopimarane diterpenoids 5 and 6, two sesquiterpenoids identified as β-eudesmol (7) and cryptomeridiol (8), and three aromatic compounds identified as phthalic acid (9), a mixture of tyrosol fatty acid esters (10) and the flavone salvigenine (11). While compounds compounds 13 showed significant inhibition of yeast α-glucosidase, compounds 2, 3 and 7 had no anti-inflammatory activity in the edema model induced by TPA. This paper is not only the first report on a wild population of Salvia cinnabarina, but also of the presence of labdane-type diterpenoids in a Mexican Salvia sp. View Full-Text
Keywords: Salvia cinnabarina; labdane diterpenoid; α-glucosidase Salvia cinnabarina; labdane diterpenoid; α-glucosidase
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Bustos-Brito, C.; Nieto-Camacho, A.; Hernandez-Ortega, S.; Rivera-Chávez, J.; Quijano, L.; Esquivel, B. Structural Elucidation of Malonylcommunol and 6β-Hydroxy-trans-communic Acid, Two Undescribed Diterpenes from Salvia cinnabarina. First Examples of Labdane Diterpenoids from a Mexican Salvia Species. Molecules 2020, 25, 1808.

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