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Molecules, Volume 25, Issue 8

April-2 2020 - 244 articles

 

Cover Story: The research of noble metals containing polyoxometalates is a challenging field that combines smart synthetic approaches and nontrivial reactivity with wide perspectives for different catalytic applications. The unique combination of ruthenium and polyoxoanions creates a new generation of water oxidation and organic substrates activation catalysts. In this report, we summarized our studies of Ru-atom reactivity inside the POM backbone towards azide. Two reaction pathways result in i) azide-acetonitrile click reaction and ii) azide decomposition. The first pathway produces coordinated tetrazole and the second generates a novel POM complex with a coordinated N2 molecule. Such reactivity is important for the transformation of organic substrates and N2 activation. View this paper.
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Articles (244)

  • Article
  • Open Access
5 Citations
4,382 Views
15 Pages

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

  • Catherine A. Tindall,
  • Sebastian Dommel,
  • Veronika Riedl,
  • David Ulbricht,
  • Stefanie Hanke,
  • Norbert Sträter and
  • John T. Heiker

24 April 2020

Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously aff...

  • Article
  • Open Access
23 Citations
5,866 Views
14 Pages

The Cytotoxic and Apoptotic Effects of the Brown Algae Colpomenia sinuosa are Mediated by the Generation of Reactive Oxygen Species

  • Reem Al Monla,
  • Zeina Dassouki,
  • Achraf Kouzayha,
  • Yahya Salma,
  • Hala Gali-Muhtasib and
  • Hiba Mawlawi

24 April 2020

Brown algae are a novel resource of biogenic molecules, however few studies have been conducted in the Mediterranean to assess the cytotoxic mechanisms of algal-derived compounds. This study focuses on the antineoplastic activity of extracts from non...

  • Brief Report
  • Open Access
13 Citations
4,760 Views
12 Pages

Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy

  • Daniel P. Feldmann,
  • Joshua Heyza,
  • Christoph M. Zimmermann,
  • Steve M. Patrick and
  • Olivia M. Merkel

24 April 2020

Platinum-based chemotherapy remains a mainstay treatment for the management of advanced non-small cell lung cancer. A key cellular factor that contributes to sensitivity to platinums is the 5′-3′ structure-specific endonuclease excision r...

  • Article
  • Open Access
7 Citations
3,950 Views
21 Pages

Fluorescent Biaryl Uracils with C5-Dihydro- and Quinazolinone Heterocyclic Appendages in PNA

  • Ali Heidari,
  • Arash Ghorbani-Choghamarani,
  • Maryam Hajjami and
  • Robert H. E. Hudson

24 April 2020

There has been much effort to exploit fluorescence techniques in the detection of nucleic acids. Canonical nucleic acids are essentially nonfluorescent; however, the modification of the nucleobase has proved to be a fruitful way to engender fluoresce...

  • Review
  • Open Access
45 Citations
7,316 Views
21 Pages

Viral Hepatitis and Iron Dysregulation: Molecular Pathways and the Role of Lactoferrin

  • Romina Mancinelli,
  • Luigi Rosa,
  • Antimo Cutone,
  • Maria Stefania Lepanto,
  • Antonio Franchitto,
  • Paolo Onori,
  • Eugenio Gaudio and
  • Piera Valenti

24 April 2020

The liver is a frontline immune site specifically designed to check and detect potential pathogens from the bloodstream to maintain a general state of immune hyporesponsiveness. One of the main functions of the liver is the regulation of iron homeost...

  • Review
  • Open Access
38 Citations
6,726 Views
20 Pages

24 April 2020

Bacterial resistance is becoming a global issue due to its rapid growth. Potential new drugs as antimicrobial peptides (AMPs) are considered for several decades as promising candidates to circumvent this threat. Nonetheless, AMPs have also been used...

  • Article
  • Open Access
41 Citations
7,537 Views
15 Pages

Potential Antimicrobial and Anticancer Activities of an Ethanol Extract from Bouea macrophylla

  • Ngoc Hong Nguyen,
  • Thuy Trang Nguyen,
  • Phu Cuong Ma,
  • Qui Thanh Hoai Ta,
  • Thuc-Huy Duong and
  • Van Giau Vo

24 April 2020

Bouea macrophylla is a tree widely grown throughout South East Asia. It is used in folk medicine for the treatment of various illnesses. The present study aimed to identify the chemical constituents and to test the antimicrobial and anticancer activi...

  • Article
  • Open Access
91 Citations
4,804 Views
11 Pages

Effect of Saturated Steam Heat Treatment on Physical and Chemical Properties of Bamboo

  • Qiuyi Wang,
  • Xinwu Wu,
  • Chenglong Yuan,
  • Zhichao Lou and
  • Yanjun Li

24 April 2020

The aim of this study was to investigate the effects of the heat treatment time and initial moisture content of bamboo on the corresponding chemical composition, crystallinity, and mechanical properties after saturated steam heat treatment at 180 &de...

  • Review
  • Open Access
98 Citations
16,870 Views
21 Pages

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening

  • Chia-Yu Chang,
  • Hsiao-Chien Ting,
  • Ching-Ann Liu,
  • Hong-Lin Su,
  • Tzyy-Wen Chiou,
  • Shinn-Zong Lin,
  • Horng-Jyh Harn and
  • Tsung-Jung Ho

24 April 2020

Neurodegenerative diseases represent a significant unmet medical need in our aging society. There are no effective treatments for most of these diseases, and we know comparatively little regarding pathogenic mechanisms. Among the challenges faced by...

  • Article
  • Open Access
12 Citations
3,919 Views
15 Pages

24 April 2020

The possibilities of metallurgical preparation of 40Nb-60Al and 15W-85Al intermetallic compounds (in at.%) by plasma arc melting (PAM) and vacuum induction melting (VIM) were studied. Both methods allow easy preparation of Nb–Al alloys; however...

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Molecules - ISSN 1420-3049