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Molecules 2019, 24(5), 999; https://doi.org/10.3390/molecules24050999

The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy

1
School of Chemistry and Chemical Engineering, Jiangxi Science and Technology Normal University, Nanchang 330013, China
2
School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China
3
School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, China
4
College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Academic Editors: David Díez and María Ángeles Castro
Received: 15 January 2019 / Revised: 7 March 2019 / Accepted: 7 March 2019 / Published: 12 March 2019
(This article belongs to the Special Issue Application of Organic Synthesis to Bioactive Compounds)
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Abstract

Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale. View Full-Text
Keywords: methyl salvianolate A; Danshen; total synthesis; Horner–Wadsworth–Emmons reaction; silyl protecting group methyl salvianolate A; Danshen; total synthesis; Horner–Wadsworth–Emmons reaction; silyl protecting group
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, B.; Wang, L.; Peng, Y.; Pang, Y.; Xiao, H.; Wang, X.; Huang, S. The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy. Molecules 2019, 24, 999.

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